Cis-Dehydrocurvularin | 122400-14-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: Cis-Dehydrocurvularin
• 英文别名: (5S,9Z)-13,15-dihydroxy-5-methyl-4-oxabicyclo[10.4.0]hexadeca-1(12),9,13,15-tetraene-3,11-dione
• CAS: 122400-14-0
• 化学式: C₁₆H₁₈O₅
• 分子量: 290.31
• InChiKey: AVIRMQMUBGNCKS-OAQKJQOQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Cis-Dehydrocurvularin 、 (4S,8E)-4,5,6,7-四氢-11,13-二羟基-4-甲基-2H-3-苯并氧杂十二环-2,10(1H)-二酮 生成 弯抱霉菌素
  参考文献：
  名称：

  LAI, SHENG;SHIZURI, YOSHIKAZU;YAMAMURA, SHOSUKE;KAWAI, KAZUAKI;TERADA, YU+, TETRAHEDRON LETT., 30,(1989) N7, C. 2241-2244

  摘要：

  DOI：

文献信息

• COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY DISEASES, CONTAINING MARINE FUNGUS PENICILLIUM SP. SF-5859-DERIVED CURVULARIN-TYPE METABOLITES
  申请人：KOREA INSITITUTE OF OCEAN SCIENCE AND TECHNOLOGY

  公开号：US20210177796A1

  公开（公告）日：2021-06-17

  The present invention relates to a pharmaceutical composition for preventing or treating inflammatory diseases and a food for preventing or alleviating inflammatory diseases, both of which contain curvularin-type metabolites as an active ingredient and, more specifically to a pharmaceutical composition for preventing or treating inflammatory diseases and a food for preventing or alleviating inflammatory diseases, both of which contain, as an active ingredient, marine fungus Penicillium sp. SF-5859-derived curvularin-type metabolites. A pharmaceutical composition, according to the present invention, for preventing or treating inflammatory diseases, containing curvularin-type metabolites derived from marine fungus Penicillium sp. SF-5859 (KCTC 13354 BP) inhibits the production of proinflammatory cytokines and mediators, thereby being effectively usable for the prevention or treatment of inflammatory diseases.