(Z)-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)-6-((Z)-3-hydroxybenzylidene)piperazine-2,5-dione | 714273-08-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (Z)-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)-6-((Z)-3-hydroxybenzylidene)piperazine-2,5-dione
• 英文别名: (3Z,6Z)-3-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]-6-[(3-hydroxyphenyl)methylidene]piperazine-2,5-dione
• CAS: 714273-08-2
• 化学式: C₁₉H₂₀N₄O₃
• 分子量: 352.393
• InChiKey: DGMFZDDDSZNGLR-SFGFDRCGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (Z)-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)-6-((Z)-3-hydroxybenzylidene)piperazine-2,5-dione 在 咪唑 、 caesium carbonate 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 24.5h， 生成
  参考文献：
  名称：

  [EN] HETEROBIFUNCTIONAL COMPOUNDS AND THEIR USE IN TREATING DISEASE
  [FR] COMPOSÉS HÉTÉROBIFONCTIONNELS ET LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES

  摘要：

  The invention provides heterobifunctional compounds, pharmaceutical compositions, and their use in treating disease, such as cancer.

  公开号：

  WO2023059605A1

文献信息

• ANALOGS OF DEHYDROPHENYLAHISTINS AND THEIR THEAPEUTIC USE
  申请人：Palladino Michael A.

  公开号：US20080221122A1

  公开（公告）日：2008-09-11

  Compounds represented by the following structure (II) are disclosed: as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.

  由以下结构（II）表示的化合物已被披露：制备这种化合物的方法也已被披露。还披露了用于治疗各种疾病条件的组合物和方法，包括与血管增殖相关的癌症和非癌症疾病。
• [EN] PLINABULIN PRODRUG ANALOGS AND THERAPEUTIC USES THEREOF<br/>[FR] ANALOGUES DE PROMÉDICAMENTS À BASE DE PLINABULINE ET UTILISATIONS THÉRAPEUTIQUES ASSOCIÉES
  申请人：TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES

  公开号：WO2012035436A1

  公开（公告）日：2012-03-22

  Compounds of Formula (I) and (I') are disclosed, as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed. (Formula (I) & (I'))

  公开了式（I）和（I'）的化合物，以及制备这些化合物的方法。还公开了用于治疗包括癌症和与血管增殖相关的非癌症疾病的组合物和方法。（式（I）和（I'））
• Analogs of dehydrophenylahistins and their therapeutic use
  申请人：Palladino Michael

  公开号：US20070078138A1

  公开（公告）日：2007-04-05

  Compounds represented by the following structure (II) are disclosed: as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.

  本文揭示了由以下结构（II）所代表的化合物，以及制造这种化合物的方法。此外，还揭示了用于治疗各种疾病状况的组合物和方法，包括与血管增殖有关的癌症和非癌症疾病。
• ANALOGS OF DEHYDROPHENYLAHISTINS AND THEIR THERAPEUTIC USE
  申请人：Palladino Michael

  公开号：US20120277251A1

  公开（公告）日：2012-11-01

  Compounds represented by the following structure (II) are disclosed: as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.

  本文披露了以下结构（II）所代表的化合物，以及制备这些化合物的方法。此外，还披露了用于治疗各种疾病状况的组合物和方法，包括与血管增生相关的癌症和非癌性疾病。
• DEHYDROPHENYLAHISTINS AND ANALOGS THEREOF AND THE SYNTHESIS OF DEHYDROPHENYLAHISTINS AND ANALOGS THEREOF
  申请人：Nereus Pharmaceuticals, Inc.

  公开号：EP1529044B1

  公开（公告）日：2007-10-03