4-异丙基-5-甲基-2-嘧啶胺 | 35733-55-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 4-异丙基-5-甲基-2-嘧啶胺
• 英文名称: 2-Amino-4-isopropyl-5-methylpyrimidin
• 英文别名: 4-isopropyl-5-methyl-pyrimidin-2-ylamine；4-Isopropyl-5-methylpyrimidin-2-amine；5-methyl-4-propan-2-ylpyrimidin-2-amine
• CAS: 35733-55-2
• 化学式: C₈H₁₃N₃
• 分子量: 151.211
• InChiKey: ICFVTTGVYSTCBY-UHFFFAOYSA-N

物化性质

• 沸点：
  297.8±43.0 °C(Predicted)
• 密度：
  1.046±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  51.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933599090

文献信息

• Inhibitors of RAS and methods of use thereof
  申请人：Araxes Pharma LLC

  公开号：US10377743B2

  公开（公告）日：2019-08-13

  Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, stereoisomer or prodrug thereof, wherein A, B, R″, Q, W, X, Y, Z, n1, n2 and are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.

  本研究提供了具有抑制 G12C 突变 KRAS 蛋白活性的化合物。这些化合物具有以下结构 (I)： 或其药学上可接受的盐、立体异构体或原药，其中 A、B、R″、Q、W、X、Y、Z、n1、n2 和如本文所定义。还提供了与制备和使用此类化合物相关的方法、包含此类化合物的药物组合物以及调节 G12C 突变 KRAS 蛋白活性以治疗疾病（如癌症）的方法。
• PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
  申请人：Nerviano Medical Sciences, S.R.L.

  公开号：US20170050972A1

  公开（公告）日：2017-02-23

  Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
• [EN] DIBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10<br/>[FR] NOUVEAUX COMPOSÉS HÉTÉROCYCLIQUES UTILES POUR TRAITER LES MALADIES ALLERGIQUES ET INFLAMMATOIRES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET PROCÉDÉS SERVANT À LES PRÉPARER
  申请人：MATRIX LAB LTD

  公开号：WO2008032171A1

  公开（公告）日：2008-03-20

  [EN] The present invention relates to novel heterocyclic compounds that are useful as phosphodiesterase inhibitors (PDEs) in particular phosphodiesterase type 4 (PDE IV) inhibitors and phosphodiesterase type 10 (PDE 10) inhibitors, processes for their preparation, pharmaceutical compositions containing them and their use in treating allergic and inflammatory diseases as well as for inhibiting the production of Tumor Necrosis Factor(TNF-a).
  [FR] L'invention concerne de nouveaux composés hétérocycliques utiles en tant qu'inhibiteurs de phosphodiestérase (PDEs), en particulier des inhibiteurs de phosphodiestérase de type 4 (PDE IV) et des inhibiteurs de phosphodiestérase de type 10 (PDE 10), des procédés servant à les préparer, des compositions pharmaceutiques les contenant et leur utilisation pour le traitement de maladies allergiques et inflammatoires, ainsi que pour inhiber la production du facteur de nécrose tumorale (TNF-a).