| 1414350-21-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• CAS: 1414350-21-2
• 化学式: C₂₇H₃₇NO₉
• 分子量: 519.592
• InChiKey: QDCLSZJLNNJGJS-ICGBEICBSA-N

反应信息

• 作为产物：
  描述：

  在 bis(cyclopentadienyl)titanium chloride 、 potassium dihydrogenphosphate 作用下， 以 四氢呋喃 、 水 为溶剂， 以32%的产率得到[(2S,3R,4R,5R,6R,7S)-5-Hydroxy-7-methoxy-8-oxo-4-phenyl-2-((4S,5R,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-1-aza-bicyclo[4.2.0]oct-3-yl]-acetic acid methyl ester
  参考文献：
  名称：

  In vitro evaluation of the antielastase activity of polycyclic β-lactams

  摘要：

  A series of bi- and tricyclic beta-lactam compounds was synthesized and evaluated as inhibitors of cleavage of synthetic substrates in vitro by the serine proteases Human Leukocyte Elastase (HLE), Human Leukocyte Proteinase 3 (HLPR3) and Porcine Pancreatic Elastase (PPE). The obtained results have permitted us to describe a homobenzocarbacephem compound as HLE and HLPR3 inhibitor, to observe the positive effect that the styryl group exerts on the HLE inhibitory activity in polycyclic beta-lactam compounds and to conclude that the hydroxyl function decreases the HLE inhibitory activity or rules it out completely. (C) 2012 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bioorg.2012.08.001