[(Cyclohexylcarbamoyl)methyl]phosphonic acid | 66959-01-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: [(Cyclohexylcarbamoyl)methyl]phosphonic acid
• 英文别名: <(N-Cyclohexylcarbamoyl)methyl>phosphonsaeure；<(Cyclohexylcarbamoyl)methyl>phosphonsaeure；[(N-Cyclohexylcarbamoyl)methyl]phosphonsaeure；[2-(cyclohexylamino)-2-oxoethyl]phosphonic acid
• CAS: 66959-01-1
• 化学式: C₈H₁₆NO₄P
• 分子量: 221.193
• InChiKey: BJGYPOFKHKASML-UHFFFAOYSA-N

物化性质

• 密度：
  1.30±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氯-n-环己基-乙酰胺 在 氢溴酸 作用下， 以 溶剂黄146 为溶剂， 反应 2.0h， 生成 [(Cyclohexylcarbamoyl)methyl]phosphonic acid
  参考文献：
  名称：

  Plant-growth-regulatingN-(phosphonoacetyl)amines

  摘要：

  AbstractA series of N‐(phosphonacetyl)amine derivatives were synthesized and screened for plant‐growth regulating activity on Lepidium sativum L. and Cucumis sativus L. Aromatic N‐(phosphonoacetyl)amines. which may be considered as possible analogues of N‐acylaniline herbicides obtained by replacement of their acyl group by the phosphonacetyl moiety, exhibited significant or moderate herbicidal activity. In contrast, N‐(phosphonoacetyl)amino acids and N‐(phosphonoacetyl)aminophosphonic acids promoted the growth of L. sativum and C. sativus roots.

  DOI：

  10.1002/ps.2780400110

文献信息

• Amides of phosphonoacetic acid for treating herpes simplex virus type 1
  申请人：Abbott Laboratories

  公开号：US04087522A1

  公开（公告）日：1978-05-02

  A method of treatng herpes simplex infection in warm-blooded animals by administering to said animals an amide of phosphonoacetic acid of the formula ##STR1## wherein R is C.sub.2 -C.sub.10 alkyl, C.sub.3 -C.sub.8 cycloalkyl, benzyl, or adamantyl; and R' is H or C.sub.2 -C.sub.10 alkyl, or its inorganic salts.

  一种治疗温血动物单纯疱疹感染的方法，通过向该动物投予磷乙酰氨基甲酸酰胺的衍生物，该衍生物的化学式为##STR1##其中R为C.sub.2 -C.sub.10 烷基，C.sub.3 -C.sub.8 环烷基，苄基或金刚烷基; R'为H或C.sub.2 -C.sub.10 烷基，或其无机盐。
• Methods and compositions to treat glycosaminoglycan-associated molecular interactions
  申请人：Kisilevsky Robert

  公开号：US20060116347A1

  公开（公告）日：2006-06-01

  Therapeutic compounds and methods for inhibiting a glycosaminoglycan (GAG)-associated molecular interaction in a subject, whatever its clinical setting, are described.

  本文描述了用于抑制受试者体内糖胺聚糖（GAG）相关分子相互作用的治疗化合物和方法，无论其临床环境如何。
• USE OF AMYLOID INHIBITORS FOR MODULATING NEURONAL CELL DEATH
  申请人：Neurochem, Inc.

  公开号：EP1077690A1

  公开（公告）日：2001-02-28
• COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN-ASSOCIATED MOLECULAR INTERACTIONS
  申请人：Neurochem, Inc.

  公开号：EP1100487A2

  公开（公告）日：2001-05-23
• Compounds and methods for modulating cerebral amyloid angiopathy
  申请人：Green Allan M.

  公开号：US20080317834A1

  公开（公告）日：2008-12-25

  The invention provides methods of inhibiting cerebral amyloid angiopathy. The invention further provides methods of treating a disease state characterized by cerebral amyloid angiopathy in a subject.