2-(4-(3-pyridyl)butyl)-1-azabicyclo[2.2.2]oct-2-ene | 1347333-14-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(4-(3-pyridyl)butyl)-1-azabicyclo[2.2.2]oct-2-ene
• 英文别名: 2-(4-(pyridin-3-yl)butyl)-1-azabicyclo[2.2.2]oct-2-ene；2-(4-Pyridin-3-ylbutyl)-1-azabicyclo[2.2.2]oct-2-ene
• CAS: 1347333-14-5
• 化学式: C₁₆H₂₂N₂
• 分子量: 242.364
• InChiKey: BYFVYAFCUOZZGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Pharmaceutical compositions and methods for use
  申请人：——

  公开号：US20030045523A1

  公开（公告）日：2003-03-06

  Pharmaceutical compositions include aryl substituted amine compounds, and in particular, carbon-linked aromatic azabicyclo compounds, and in particular, aromatic alkylene azabicyclo compounds and aromatic alkyl azabicyclo compounds.

  药物组合物包括芳基取代胺化合物，特别是碳链芳香族氮杂双环化合物，特别是芳基烷基氮杂双环化合物和芳基烷基氮杂双环化合物。
• PYRDIYL-BRIIDGEHEAD DERIVATIVES AND THEIR ANALOGUES, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS
  申请人：R.J. REYNOLDS TOBACCO COMPANY

  公开号：EP1053236A1

  公开（公告）日：2000-11-22
• US6432975B1
  申请人：——

  公开号：US6432975B1

  公开（公告）日：2002-08-13
• [EN] PYRIDYL-BRIDGEHEAD DERIVATIVES AND THEIR ANALOGUES, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS<br/>[FR] DERIVES A TETE DE PONT PYRIDYLE ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES ET LEUR UTILISATION COMME INHIBITEURS DES RECEPTEURS CHOLINERGIQUES NICOTINIQUES
  申请人：REYNOLDS TOBACCO CO R

  公开号：WO2000034276A1

  公开（公告）日：2000-06-15

  Pharmaceutical compositions include aryl substituted amine compounds, and in particular, carbon-linked aromatic azabicyclo compounds, and in particular, aromatic alkylene azabicyclo compounds and aromatic alkyl azabicyclo compounds of formula (I) and formula (II) capable of acting to inhibit function of certain nicotinic cholinergic receptors.