1-((1-tosylpyrrolidin-2-yl)methyl)-1H-imidazole | 1252879-97-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-((1-tosylpyrrolidin-2-yl)methyl)-1H-imidazole
• CAS: 1252879-97-2
• 化学式: C₁₅H₁₉N₃O₂S
• 分子量: 305.401
• InChiKey: PZZFKMFUNCVXDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.04
• 重原子数：
  21.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  55.2
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  1-((1-tosylpyrrolidin-2-yl)methyl)-1H-imidazole 、 碘甲烷 以 乙腈 为溶剂， 以92%的产率得到
  参考文献：
  名称：

  Palladium(II)–N-heterocyclic carbene complexes derived from proline: synthesis and characterization

  摘要：

  Pd(II)-N-heterocyclic carbene complexes derived from proline have been successfully synthesized in good yields and their structures have been characterized by X-ray single crystal diffraction. It was found that the substituents on the N-atom of the pyrrolidine skeleton dramatically affect on the coordination pattern of the palladium complexes. In a word, when an electron-rich group as benzyl group was attached on the N-atom, both of the N-atom and NHC were coordinated to the Pd(II) center; while when an electron-poor group as Ts group was attached, a dimeric mono-coordinated Pd(II)-NHC was obtained exclusively. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.08.021
• 作为产物：
  描述：

  (1-tosylpyrrolidin-2-yl)methyl 4-methylbenzenesulfonate 、 咪唑钠 以 四氢呋喃 为溶剂， 反应 24.0h， 以89%的产率得到1-((1-tosylpyrrolidin-2-yl)methyl)-1H-imidazole
  参考文献：
  名称：

  Palladium(II)–N-heterocyclic carbene complexes derived from proline: synthesis and characterization

  摘要：

  Pd(II)-N-heterocyclic carbene complexes derived from proline have been successfully synthesized in good yields and their structures have been characterized by X-ray single crystal diffraction. It was found that the substituents on the N-atom of the pyrrolidine skeleton dramatically affect on the coordination pattern of the palladium complexes. In a word, when an electron-rich group as benzyl group was attached on the N-atom, both of the N-atom and NHC were coordinated to the Pd(II) center; while when an electron-poor group as Ts group was attached, a dimeric mono-coordinated Pd(II)-NHC was obtained exclusively. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.08.021