10,20-dimethyl-3,7,11,19-tetraoxa-2,8-dioxo-12,12,18,18-tetraphenyltricyclo[15.3.0.0(9,13)]icosa-9,20-diene | 1224126-87-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 10,20-dimethyl-3,7,11,19-tetraoxa-2,8-dioxo-12,12,18,18-tetraphenyltricyclo[15.3.0.0(9,13)]icosa-9,20-diene
• CAS: 1224126-87-7
• 化学式: C₄₂H₄₀O₆
• 分子量: 640.776
• InChiKey: IPFKEUOWMZFBFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.38
• 重原子数：
  48.0
• 可旋转键数：
  4.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  71.06
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  1,1,7,7-Tetraphenyl-1,6-heptadiene 、 propane-1,3-diyl bis(3-oxobutanoate) 在 manganese(III) triacetate dihydrate 、 溶剂黄146 作用下， 反应 0.83h， 以67%的产率得到10,20-dimethyl-3,7,11,19-tetraoxa-2,8-dioxo-12,12,18,18-tetraphenyltricyclo[15.3.0.0(9,13)]icosa-9,20-diene
  参考文献：
  名称：

  Efficient macrocyclization using methylene-tethered terminal dienes and bis(manganese(III)-enolate)s

  摘要：

  Macrocyclic compounds, which have two fused dihydrofuran rings, were synthesized with complete control by the oxidation of alpha,alpha,omega,omega-tetraaryl-alpha(omega-1)-alkadienes 1(x) with manganese(III)-oligomethylenebis(enolate) complexes directly formed by the reaction of the ohgomethylene bis(3-oxobutanoate)s 2(y) with manganese(III) acetate in situ The oxamethylene-tethered macrodiolides 5 and 7 were also produced in good to moderate yields by a similar oxidation The key intermediate, an election donor-acceptor-like complex, was proposed for the efficient macrocyclization reaction (C) 2010 Elsevier Ltd. All rights reserved

  DOI：

  10.1016/j.tet.2010.02.022