(Z)-2-(((E)-6-(2-chlorobenzylidene)-7-oxo-9-phenyl-6,7-dihydro-7H-[1,2,3,4]tetrazolo[1,5-a][1,4]diazepin-8(9H)-yl)methyl)-3-phenylacrylonitrile | 1207105-12-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-2-(((E)-6-(2-chlorobenzylidene)-7-oxo-9-phenyl-6,7-dihydro-7H-[1,2,3,4]tetrazolo[1,5-a][1,4]diazepin-8(9H)-yl)methyl)-3-phenylacrylonitrile
• CAS: 1207105-12-1
• 化学式: C₂₈H₂₁ClN₆O
• 分子量: 492.967
• InChiKey: RTGUGJVFOXVYCG-XMGKXQPASA-N

反应信息

• 作为产物：
  描述：

  (E)-3-(2-chlorophenyl)-2-({5-[((Z)-2-cyano-3-phenylallylamino)(phenyl)methyl]-1H-1,2,3,4-tetrazol-1-yl}methyl)prop-2-enoic acid 在 N-甲基吗啉 、 N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride 作用下， 以 二氯甲烷 为溶剂， 反应 2.17h， 以82%的产率得到(Z)-2-(((E)-6-(2-chlorobenzylidene)-7-oxo-9-phenyl-6,7-dihydro-7H-[1,2,3,4]tetrazolo[1,5-a][1,4]diazepin-8(9H)-yl)methyl)-3-phenylacrylonitrile
  参考文献：
  名称：

  Isonitriles from the Baylis–Hillman adducts of acrylates: viable precursor to tetrazolo-fused diazepinones via post-Ugi cyclization

  摘要：

  Stereocontrolled synthesis of substituted isonitriles from the Baylis-Hillman adducts of acrylates has been developed. Ugi reaction of these isonitriles with TMSN3, aliphatic amines, and aldehydes or ketone affords 1-substituted tetrazoles which have been demonstrated to be suitable substrates for producing tetrazolo-fused diazepinones. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.11.051