3-(3,4-dimethoxyphenyl)-2,3-dihydro[1,3]dioxolo[4,5-f][1,2]benzisothiazole 1,1-dioxide | 1222561-47-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(3,4-dimethoxyphenyl)-2,3-dihydro[1,3]dioxolo[4,5-f][1,2]benzisothiazole 1,1-dioxide
• CAS: 1222561-47-8
• 化学式: C₁₆H₁₅NO₆S
• 分子量: 349.364
• InChiKey: JLTSKHZUZMRJRY-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  N-t-butyl-6-[1-(3,4-dimethoxyphenyl)-1-hydroxymethyl]-benzo[d][1,3]dioxole-5-sulfonamide 在 三甲基氯硅烷 、 碘 、 sodium iodide 作用下， 以 乙腈 为溶剂， 以84%的产率得到3-(3,4-dimethoxyphenyl)-2,3-dihydro[1,3]dioxolo[4,5-f][1,2]benzisothiazole 1,1-dioxide
  参考文献：
  名称：

  Iodotrimethylsilane and Catalytic Iodine Promoted Cyclization for the Facile Synthesis of 3-Monoarylated Five-Membered Benzosultams

  摘要：

  3-Monoarylated five-membered benzosultams with various functional groups were prepared by simple and convenient two-step procedures. N-t-Bu-benzenesulfonamides were lithiated and reacted with substituted aromatic aldehydes to form the corresponding carbinols, which were converted to the cyclic compounds via a sequence of consecutive processes mediated by TMSCl-NaI-MeCN reagent and catalytic amount of iodine. Iodine played a crucial role in the eliminating the reductive side reaction in the cyclization processes.

  DOI：

  10.3987/com-09-11884