3-aminomethyl-4,6-dimethyl-2-methylthiopyridine | 445471-13-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 3-aminomethyl-4,6-dimethyl-2-methylthiopyridine
• 英文别名: (4,6-dimethyl-2-methylsulfanylpyridin-3-yl)methanamine
• CAS: 445471-13-6
• 化学式: C₉H₁₄N₂S
• mdl: MFCD03034825
• 分子量: 182.29
• InChiKey: KPIGWSGKDXXPBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  64.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-甲基-3-硝基苯甲酰氯 、 3-aminomethyl-4,6-dimethyl-2-methylthiopyridine 在 三乙胺 作用下， 以 乙腈 为溶剂， 以71%的产率得到N-{[4,6-dimethyl-2-(methylsulfanyl)pyridin-3-yl]methyl}-2-methyl-3-nitrobenzamide
  参考文献：
  名称：

  摘要：

  The reactions of substituted 3-cyanopyridine-2(1H)-thiones and 3-cyano-2-(methylthio)pyridines with lithium aluminum hydride in anhydrous diethyl ether afforded the corresponding 3-aminomethyl derivatives, which were used in the synthesis of the corresponding amides.

  DOI：

  10.1023/a:1024472914598
• 作为产物：
  描述：

  3-cyano-4,6-dimethyl-2-methylthiopyridine 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 1.0h， 以59%的产率得到3-aminomethyl-4,6-dimethyl-2-methylthiopyridine
  参考文献：
  名称：

  摘要：

  The reactions of substituted 3-cyanopyridine-2(1H)-thiones and 3-cyano-2-(methylthio)pyridines with lithium aluminum hydride in anhydrous diethyl ether afforded the corresponding 3-aminomethyl derivatives, which were used in the synthesis of the corresponding amides.

  DOI：

  10.1023/a:1024472914598

文献信息

• Reductive desulfurization of 3-cyano-2-methylthiopyridines under the action of Raney nickel
  作者：A. A. Zubarev、V. K. Zav’yalova、V. P. Litvinov

  DOI：10.1007/s11172-006-0158-6

  日期：2005.11

  The action of Raney nickel on substituted 3-cyano-2-methylthiopyridines was studied. Under conditions of catalytic hydrogenation, the reaction yields a mixture containing the aminosulfide resulting from reduction of the nitrile group with retention of the methylthio group, the nitrile resulting from elimination of the methylthio group, and the amine resulting from both reduction of the nitrile group

  研究了雷尼镍对取代的 3-氰基-2-甲基硫代吡啶的作用。在催化加氢条件下，反应生成的混合物含有由腈基还原而保留甲硫基的氨基硫化物、由甲硫基消除的腈和由腈基和甲硫基同时还原产生的胺。消除甲硫基。在脱硫条件下用大量阮内镍处理 3-氰基-2-甲硫基吡啶可同时消除甲硫基和将腈基还原为氨基甲基。在甲醇或四氢呋喃中还原脱硫生成伯胺，而在异丙醇或乙醇中反应生成仲胺或叔胺，
• Sodium bis(2-methoxyethoxy)aluminum hydride in reactions with 3-cyano-6-methylpyridine-2(1H)-thione and 3-cyano-6-methyl(4,6-dimethyl)-2-methylthiopyridines
  作者：A. A. Zubarev、V. K. Zav"yalova、V. P. Litvinov

  DOI：10.1023/b:rucb.0000035647.06853.80

  日期：2004.3

  The reactions of sodium bis(2-methoxyethoxy)aluminum hydride with 3-cyano-6-methylpyridine-2(1H)-thione and 3-cyano-6-methyl-2-methylthiopyridine afforded 3-aminomethyl-6-methylpyridine-2(1H)-thione and azomethine of the pyridine series, respectively. The corresponding reaction with 3-cyano-4,6-dimethyl-2-methylthiopyridine gave rise to azomethine, substituted 3-aminomethylpyridine, and substituted

  双(2-甲氧基乙氧基)铝氢化钠与3-氰基-6-甲基吡啶-2(1H)-硫酮和3-氰基-6-甲基-2-甲基硫吡啶反应生成3-氨基甲基-6-甲基吡啶-2(分别为吡啶系列的 1H)-硫酮和偶氮甲碱。与3-氰基-4,6-二甲基-2-甲基硫吡啶的相应反应产生偶氮甲碱、取代的3-氨基甲基吡啶和取代的二吡啶基甲烷。