2,4,6-trimethylbenzaldehyde N-(2,4,6-trimethylbenzoyl)hydrazone | 15824-12-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4,6-trimethylbenzaldehyde N-(2,4,6-trimethylbenzoyl)hydrazone
• 英文别名: N-(2,4,6-trimethylbenzoyl)hydrazone；2,4,6-Trimethyl-benzaldehyd-2,4,6-trimethyl-benzoyl-hydrazon；2,4,6-trimethyl-N-[(2,4,6-trimethylphenyl)methylideneamino]benzamide
• CAS: 15824-12-1
• 化学式: C₂₀H₂₄N₂O
• 分子量: 308.423
• InChiKey: HFFLGDFOFHXSFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,3,5-三甲基-2-(三氯甲基)苯 在 2,6-二甲基吡啶 、 盐酸肼 作用下， 以 水 为溶剂， 反应 1.0h， 以26%的产率得到2,4,6-trimethylbenzaldehyde N-(2,4,6-trimethylbenzoyl)hydrazone
  参考文献：
  名称：

  An alternative channel of reductive condensation of trichloromethylarenes with hydrazines

  摘要：

  The reductive condensation of trichloromethylarenes with hydrazines can proceed without intermediate formation of pyridinium salts and without participation of pyridine in the reduction act. Variants of reductive condensation using hydrazines as reducting agents and alpha-chlorobenzylhydrazines and hydrazonoyl chlorides, nitrile imines, or hydrazonoylpyridinium salts as intermediates are considered, alpha-Chlorobenzylhydmzines and hydrazonoyl chlorides are shown to be the most probable intermediates.

  DOI：

  10.1007/bf02494714

文献信息

• Initial steps in the reductive condensation of trichloromethylarenes with hydroxylamine and hydrazines in pyridine
  作者：L. I. Belen'kii、I. S. Poddubnyi、M. M. Krayushkin

  DOI：10.1007/bf00699000

  日期：1993.11

  Data concerning the initial steps in the reductive condensation of trichloromethylarenes with hydroxylamine or hydrazines in pyridine have been obtained. High yields of the products of the reductive condensation obtained even at equimolar ratios of trichloromethylarene with hydroxylamine or hydrazine as well as the formation of unusual products, i.e., 4-pyridylhydrazones of substituted benzaldehydes, have been interpreted as the result of the participation of pyridine in the reaction as a reductive agent.