{(R)-1-[2-[(S)-2-{5-methyl-7-[(tetrahydro-pyran-4-ylmethyl)-amino]-1H-indol-2-yl}-4,5-dihydro-thiazol-4-yl]-ethyl]-pyrrolidin-2-yl}-methaneol | 1120344-58-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: {(R)-1-[2-[(S)-2-{5-methyl-7-[(tetrahydro-pyran-4-ylmethyl)-amino]-1H-indol-2-yl}-4,5-dihydro-thiazol-4-yl]-ethyl]-pyrrolidin-2-yl}-methaneol
• 英文别名: [(2R)-1-[2-[(4S)-2-[5-methyl-7-(oxane-4-ylmethylamino)-1H-indole-2-yl]-4,5-dihydro-1,3-thiazole-4-yl]ethyl]pyrrolidine-2-yl]methanol；[(2R)-1-[2-[(4S)-2-[5-methyl-7-(oxan-4-ylmethylamino)-1H-indole-2-yl]-4,5-dihydro-1,3-thiazol-4-yl]ethyl]pyrrolidin-2-yl]methanol；[(2R)-1-[2-[(4S)-2-[5-methyl-7-(oxan-4-ylmethylamino)-1H-indol-2-yl]-4,5-dihydro-1,3-thiazol-4-yl]ethyl]pyrrolidin-2-yl]methanol
• CAS: 1120344-58-2
• 化学式: C₂₅H₃₆N₄O₂S
• 分子量: 456.652
• InChiKey: QYQHMTBXLBCVSW-LEWJYISDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  98.2
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT
  申请人：Kim Soon Ha

  公开号：US20100267708A1

  公开（公告）日：2010-10-21

  The present invention relates to new compounds of formula (1) exhibiting excellent activity for glucokinase, and pharmaceutical compositions comprising the same as an active ingredient.

  本发明涉及公式（1）的新化合物，表现出对葡萄糖激酶的优异活性，并且包括该化合物作为活性成分的药物组合物。
• INDOLE AND INDAZOLE DERIVATIVES HAVING A CELL-, TISSUE- AND ORGAN-PRESERVING EFFECT
  申请人：Kim Soon Ha

  公开号：US20100291533A1

  公开（公告）日：2010-11-18

  The present invention relates to a composition for preserving cells, tissues and organs, comprising as an active ingredient indole and indazole compounds of formula (1), or a pharmaceutically acceptable salt or isomer thereof, which are effective for preventing injury of organs, isolated cell systems or tissues caused by cold storage, transplant operation or post-transplantation reperfusion; a preservation method; and a preparation method of the composition.

  本发明涉及一种用于保存细胞、组织和器官的组合物，其中包括作为活性成分的式（1）的吲哚和吲唑化合物，或其药用可接受的盐或异构体，对于预防由冷藏、移植手术或移植后再灌注引起的器官、分离的细胞系统或组织的损伤具有有效性；一种保存方法；以及该组合物的制备方法。
• US8309586B2
  申请人：——

  公开号：US8309586B2

  公开（公告）日：2012-11-13
• US8349885B2
  申请人：——

  公开号：US8349885B2

  公开（公告）日：2013-01-08
• [EN] GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT<br/>[FR] ACTIVATEURS DE LA GLUCOKINASE ET COMPOSITIONS PHARMACEUTIQUES CONTENANT CES DERNIERS EN TANT QU'INGRÉDIENT ACTIF
  申请人：LG LIFE SCIENCES LTD

  公开号：WO2009082152A2

  公开（公告）日：2009-07-02

  The present invention relates to new compounds of formula (1) exhibiting excellent activity for glucokinase, and pharmaceutical compositions comprising the same as an active ingredient.