Asymmetric Synthesis of .beta.-Lactams. Highly Diastereoselective Alkylation of Chiral 2-Cyano Esters
作者:Carlos Cativiela、Maria D. Diaz-de-Villegas、Jose A. Galvez
DOI:10.1021/jo00088a034
日期:1994.5
Enolates derived from 10-(dicyclohexylsulfamoyl)isobornyl 2-substituted-2-cyanoacetates were alkylated with very good yield and high diastereoselectivity. The reduction of the resulting reaction products and subsequent cyclization of the p-amino acids led to the corresponding beta-lactam in high yields. This result paves the way for the development of a versatile and efficient asymmetric synthesis of enantiomerically pure (R)- and (S)-C(3)-disubstituted beta-lactams.
Testa et al., Justus Liebigs Annalen der Chemie, 1959, vol. 626, p. 121
作者:Testa et al.
DOI:——
日期:——
Fontanella; Testa, Justus Liebigs Annalen der Chemie, 1958, vol. 616, p. 148,151