| 1220098-04-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1220098-04-3
• 化学式: C₂₃H₁₈F₃NO₂S
• 分子量: 429.463
• InChiKey: DLAFMAISABVIHW-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 水 、 lithium hydroxide 作用下， 以 四氢呋喃 为溶剂， 生成 C₂₂H₁₆F₃NO₂S
  参考文献：
  名称：

  Exploration of SAR features by modifications of thiazoleacetic acids as CRTH2 antagonists

  摘要：

  The SAR features have been further explored for (2-benzhydryl-4-phenyl-thiazol-5-yl) acetic acids as CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) antagonists. The introduction of a nitrogen or a methyl substituent in the benzhydrylic position offer two alternative drugable scaffolds attractive for unsymmetrically substituted derivatives. An imidazole analogue lacks activity due to formation of a favored coplanar intramolecular hydrogen bond. The pyrimidine derivative 18 represents a potent and selective compound that will be subject to continued investigations. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.092
• 作为产物：
  描述：

  在 劳森试剂 作用下， 以 甲苯 为溶剂， 生成
  参考文献：
  名称：

  Exploration of SAR features by modifications of thiazoleacetic acids as CRTH2 antagonists

  摘要：

  The SAR features have been further explored for (2-benzhydryl-4-phenyl-thiazol-5-yl) acetic acids as CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) antagonists. The introduction of a nitrogen or a methyl substituent in the benzhydrylic position offer two alternative drugable scaffolds attractive for unsymmetrically substituted derivatives. An imidazole analogue lacks activity due to formation of a favored coplanar intramolecular hydrogen bond. The pyrimidine derivative 18 represents a potent and selective compound that will be subject to continued investigations. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.092