4-({[7-chloro-2-(2-chloro-6-fluorophenyl)-1H-benzimidazole-5-carbonyl]-amino})-piperidine-1-carboxylic acid tert-butyl ester | 1329118-08-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 4-({[7-chloro-2-(2-chloro-6-fluorophenyl)-1H-benzimidazole-5-carbonyl]-amino})-piperidine-1-carboxylic acid tert-butyl ester
• 英文别名: tert-butyl 4-[[7-chloro-2-(2-chloro-6-fluorophenyl)-3H-benzimidazole-5-carbonyl]amino]piperidine-1-carboxylate
• CAS: 1329118-08-2
• 化学式: C₂₄H₂₅Cl₂FN₄O₃
• 分子量: 507.392
• InChiKey: PCSJUDYYIDTYNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  87.3
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] NOVEL BENZIMIDAZOLE COMPOUND, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME<br/>[FR] NOUVEAU COMPOSÉ DE BENZIMIDAZOLE, SON PROCÉDÉ DE PRÉPARATION ET COMPOSITION PHARMACEUTIQUE LE CONTENANT
  申请人：CRYSTALGENOMICS INC

  公开号：WO2011099832A2

  公开（公告）日：2011-08-18

  The present invention relates to a novel benzimidazole compound, a pharmaceutical composition for preventing or treating an inflammatory disease comprising said compound, a use of a novel benzimidazole compound for the manufacture of a medicament for preventing or treating an inflammatory disease, and a method of preventing or treating an inflammatory disease in a mammal comprising administering to the mammal said compound.