2-amino-4-methyl-6-(1H-pyrazol-5-yl)-8-(tetrahydro-2H-pyran-3-yl)pyrido[2,3-d]pyrimidin-7(8H)-one | 1071829-31-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-amino-4-methyl-6-(1H-pyrazol-5-yl)-8-(tetrahydro-2H-pyran-3-yl)pyrido[2,3-d]pyrimidin-7(8H)-one
• 英文别名: 2-amino-4-methyl-8-(oxan-3-yl)-6-(1H-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7-one
• CAS: 1071829-31-6
• 化学式: C₁₆H₁₈N₆O₂
• 分子量: 326.358
• InChiKey: BLVOBRJOMRUEJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• PYRIDO [2, 3-D] PYRIMIDIN-7-ONE COMPOUNDS AS INHIBITORS OF P13K-ALPHA FOR THE TREATMENT OF CANCER
  申请人：Buhr Chris A.

  公开号：US20100209340A1

  公开（公告）日：2010-08-19

  The invention is directed to Compounds of Formula (I). The invention provides compounds that inhibit, regulate, and/or modulate P13K that are useful in the treatment of hyperproliferative diseases, such as cancer.

  该发明涉及式(I)化合物。该发明提供了抑制、调节和/或调控P13K的化合物，这些化合物在治疗高增殖性疾病，如癌症方面是有用的。
• Pyrido [2, 3-D] pyrimidin-7-one compounds as inhibitors of P13K-Alpha for the treament of cancer
  申请人：Exelixis, Inc.

  公开号：US20130343988A1

  公开（公告）日：2013-12-26

  The invention is directed to Compounds of Formula (I). The invention provides compounds that inhibit, regulate, and/or modulate P13K that are useful in the treatment of hyperproliferative diseases, such as cancer.

  本发明涉及式(I)的化合物。本发明提供抑制、调节和/或调节P13K的化合物，这些化合物在治疗过度增殖性疾病，如癌症方面是有用的。
• PYRIDO [2, 3-D]PYRIMIDIN-7-ONE COMPOUNDS AS INHIBITORS OF PI3K-ALPHA FOR THE TREATMENT OF CANCER
  申请人：Exelixis, Inc.

  公开号：EP2142544A1

  公开（公告）日：2010-01-13
• [EN] PYRIDO [2, 3-D] PYRIMIDIN-7-ONE COMPOUNDS AS INHIBITORS OF PI3K-ALPHA FOR THE TREATMENT OF CANCER<br/>[FR] COMPOSÉS PYRIDO [2, 3-D] PYRIMIDIN-7-ONE UTILISÉS EN TANT QU'INHIBITEURS DE PI3K-ALPHA POUR LE TRAITEMENT DU CANCER
  申请人：EXELIXIS INC

  公开号：WO2008127712A1

  公开（公告）日：2008-10-23

  [EN] The invention is directed to Compounds of Formula (I). The invention provides compounds that inhibit, regulate, and/or modulate P13K that are useful in the treatment of hyperproliferative diseases, such as cancer.
  [FR] L'invention concerne des composés de formule (I). Les composés de l'invention inhibent, régulent, et/ou modulent l'activité de la kinase P13K et sont utiles dans le traitement de maladies hyperprolifératives, comme le cancer.