Benzeneacetaldehyde, alpha-ethenyl- | 87745-61-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzeneacetaldehyde, alpha-ethenyl-
• 英文别名: 2-phenylbut-3-enal
• CAS: 87745-61-7
• 化学式: C₁₀H₁₀O
• 分子量: 146.189
• InChiKey: KOTCAHMHPWDPOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Benzeneacetaldehyde, alpha-ethenyl- 以70%的产率得到
  参考文献：
  名称：

  BARBOT, F.;MIGINIAC, PH., SYNTHESIS, BRD, 1983, N 8, 651-654

  摘要：

  DOI：
• 作为产物：
  描述：

  1,1-Dimethoxybut-3-en-2-ylbenzene 在 甲酸 作用下， 以 正戊烷 为溶剂， 反应 1.0h， 生成 Benzeneacetaldehyde, alpha-ethenyl-
  参考文献：
  名称：

  Preparation of 3-Alkenals and 3-Alkynals by Hydrolysis of the Corresponding Acetals

  摘要：

  DOI：

  10.1055/s-1983-30461

文献信息

• [EN] MACROMOLECULAR COMPOSITIONS FOR BINDING SMALL MOLECULES<br/>[FR] COMPOSITIONS MACROMOLÉCULAIRES POUR LA LIAISON DE PETITES MOLÉCULES
  申请人：STICHTING TECHNISCHE WETENSCHAPPEN

  公开号：WO2021099577A1

  公开（公告）日：2021-05-27

  The present invention relates to a method for preparing a macromolecular composition comprising phenylglyoxaldehyde-derivatives. The invention also relates to the macromolecular compositions per se, and to methods of using the macromolecular compositions. The macromolecular compositions are useful for undergoing subsequent reactions with small molecules, for instance to remove such small molecules from a solution.

  本发明涉及一种制备含苯甘醛衍生物的大分子组合物的方法。该发明还涉及大分子组合物本身，以及使用该大分子组合物的方法。这些大分子组合物可用于与小分子进行后续反应，例如从溶液中去除这些小分子。
• [EN] HYDROXAMATES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS<br/>[FR] HYDROXAMATES, LEUR FABRICATION ET LEUR UTILISATION COMME AGENTS PHARMACEUTIQUES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2005121119A1

  公开（公告）日：2005-12-22

  Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

  本发明的对象是式(I)的化合物，其药学上可接受的盐、对映体、顺反异构体和混合物，上述化合物的制备，包含它们的药物以及其制造，以及上述化合物在控制或预防癌症等疾病中的使用。
• COMBINATION OF MODAFINIL AND AN ANTAGONIST OR INVERSE AGONIST OF THE H3 RECEPTOR
  申请人：Schwartz Jean-Charles

  公开号：US20090312367A1

  公开（公告）日：2009-12-17

  The invention relates to a combination of modafinil and at least one histamine H3 receptor antagonist or inverse agonist, which can be used in particular for the treatment of narcolepsy-cataplexy and more generally for disorders of sleep, wakefulness and vigilance.

  本发明涉及调节药物莫达非尼和至少一种组胺H3受体拮抗剂或反向激动剂的组合，特别适用于治疗嗜睡症-猝倒症，更广泛地适用于睡眠、清醒和警觉障碍的治疗。
• Non-imidazole alkylamines as histamine H3-receptor ligands and their therapeutic applications
  申请人：——

  公开号：US20040220225A1

  公开（公告）日：2004-11-04

  Use of a compound of formula (A), wherein: 1 W is a residue which imparts antagonistic and/or agonistic activity at histamine H 3 -receptors when attached to an imidazole ring in 4(5) position; R 1 and R 2 may be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H 3 -receptors of histamine.

  使用式(A)的化合物，其中：1W是一个残基，当附加在咪唑环的4(5)位时，赋予组合物在组胺H3受体上的拮抗和/或激动活性；R1和R2可以相同也可以不同，分别独立地表示较低的烷基或环烷基，或者与它们所连接的氮原子一起，表示饱和的含氮环(i)、非芳香性不饱和含氮环(ii)、吗啡环或N-取代哌嗪环，用于制备在组胺H3受体上作为拮抗剂和/或激动剂的药物。
• Non-imidazole alkylamines as histamine H3- receptor ligands and their therapeutic applications
  申请人：Schwartz Jean-Charles

  公开号：US20060247223A1

  公开（公告）日：2006-11-02

  Use of a compound of formula (A), wherein: W is a residue which imparts antagonistic and/or agonistic activity at histamine H 3 -receptors when attached to an imidazole ring in 4(5) position; R 1 and R 2 may be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H 3 -receptors of histamine.

  使用公式（A）中的化合物，其中： W是一个残留物，当附加到咪唑环的4（5）位时，赋予组织胺H3受体的拮抗和/或激动活性； R1和R2可以相同也可以不同，并且独立地表示较低的烷基或环烷基，或者与它们附着的氮原子一起，表示饱和的含氮环（i）如定义，非芳香性不饱和含氮环（ii）如定义，吗啉基或N-取代的哌嗪基，如定义，用于制备作为组织胺H3受体的拮抗剂和/或激动剂的药物。