2,3-dihydroxypropyl N-butylcarbamate | 129159-58-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 2,3-dihydroxypropyl N-butylcarbamate
• CAS: 129159-58-6
• 化学式: C₈H₁₇NO₄
• 分子量: 191.227
• InChiKey: RGZVJDGSFAVRGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  78.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  羟甲基二氧杂戊环酮 、 正丁胺 以 水 为溶剂， 生成 1,3-dihydroxypropan-2-yl N-butylcarbamate 、 2,3-dihydroxypropyl N-butylcarbamate 、 甘油
  参考文献：
  名称：

  碳酸甘油酯在有机和有机介质中的氨解反应

  摘要：

  AbstractAminolysis reaction of glycerol carbonate with primary amine in organic and hydroorganic media leads to the formation of two hydroxyurethane isomers and a partial decomposition of glycerol carbonate into glycerol. Aminolysis with a secondary amine promotes the condensation reaction and limits the formation of glycerol. The ratio of α versus β was determined by zgig 13C NMR. This technique permits computing the yield of α and β products in the medium. The quantity of glycerol was determined by GC analysis. The ratio of the isomers and the amount of glycerol depend on the amine and the solvent. Kinetic investigations reveal that, in hydroorganic medium, the more the alkyl chain of the amine increased, the less glycerol was formed. On the contrary, in organic medium, the alkyl chain of the amine does not play a major role in the formation of glycerol.

  DOI：

  10.1007/s11746-011-1995-5

文献信息

• Aqueous high solids coating compositions
  申请人：UNION CARBIDE CORPORATION

  公开号：EP0196112A2

  公开（公告）日：1986-10-01

  Water borne high solids coating compositions are made by blending a water-dispersible, crosslinkable organic polymer, water, at least one reactive carbamate derivative, a crosslinking agent and optionally a crosslinking catalyst. The resultant water borne high solids coating compositions can be either solutions or dispersions depending upon the particular polymer and reactive carbamate chosen as the reactive cosolvent or reactive diluent.

  水性高固体份涂料组合物是通过混合水分散性可交联有机聚合物、水、至少一种活性氨基甲酸酯衍生物、交联剂和交联催化剂制成的。根据作为反应性助溶剂或反应性稀释剂的特定聚合物和反应性氨基甲酸酯的选择，所得到的水性高固体份涂料组合物既可以是溶液，也可以是分散体。
• High solids coating compositions
  申请人：UNION CARBIDE CORPORATION

  公开号：EP0211359A1

  公开（公告）日：1987-02-25

  High solids coating compositions are made by blending a crosslinkable organic polymer, a solvent, at least one reactive urea derivative, a crosslinking agent and optionally a crosslinking catalyst. The resultant high solids coating compositions can be either solutions or dispersions depending upon the particular polymer and solvent and the reactive urea chosen as the reactive cosolvent or reactive diluent. The reactive urea derivatives can be mixed with reactive carbamate derivatives.

  高固体份涂料组合物是通过混合可交联有机聚合物、溶剂、至少一种活性脲衍生物、交联剂和交联催化剂制成的。根据特定的聚合物和溶剂以及作为反应性助溶剂或反应性稀释剂的活性脲的选择，所得到的高固体份涂料组合物可以是溶液或分散体。活性脲衍生物可与活性氨基甲酸酯衍生物混合。
• CARBAMATE COATING COMPOSITIONS
  申请人：UNION CARBIDE CORPORATION

  公开号：EP0233253A1

  公开（公告）日：1987-08-26
• SOLVENT BORNE HIGH SOLIDS COATING COMPOSITIONS
  申请人：UNION CARBIDE CORPORATION

  公开号：EP0285650A1

  公开（公告）日：1988-10-12
• FATTY ACID CYSTEAMINE CONJUGATES AND THEIR USE AS ACTIVATORS OF AUTOPHAGY
  申请人：Catabasis Pharmaceuticals, Inc.

  公开号：US20200038342A1

  公开（公告）日：2020-02-06

  The invention relates to fatty acid cysteamine conjugates, compositions comprising a fatty acid cysteamine conjugate, and methods for using such conjugates and compositions to treat disease, such as a disease caused by dysregulation of autophagy.