5-((4-(2-(5-ethyl-2-pyridyl)-1-oxoethoxy)phenyl)methyl)-2,4-thiazolidinedione | 1070112-66-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 5-((4-(2-(5-ethyl-2-pyridyl)-1-oxoethoxy)phenyl)methyl)-2,4-thiazolidinedione
• 英文别名: 5-((4-(2-(5-ethyl-2-pyridyl)-1-oxoethoxy)phenyl) methyl)thiazolidin2,4-dione；[4-[(2,4-Dioxo-1,3-thiazolidin-5-yl)methyl]phenyl] 2-(5-ethylpyridin-2-yl)acetate
• CAS: 1070112-66-1
• 化学式: C₁₉H₁₈N₂O₄S
• 分子量: 370.429
• InChiKey: ADJGILYWRFPXQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  111
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• PPAR-SPARING THIAZOLIDINEDIONE SALTS FOR THE TREATMENT OF METABOLIC DISEASES
  申请人：Colca Gerard R.

  公开号：US20120309975A1

  公开（公告）日：2012-12-06

  The present invention relates to novel salts of thiazolidinediones and other pharmaceutical agents that are useful for treating and/or preventing metabolic diseases (e.g., diabetes, or neurodegenerative diseases (e.g., Alzheimer's Disease).

  本发明涉及一种新型噻唑烷二酮盐和其他药物制剂，其用于治疗和/或预防代谢性疾病（如糖尿病）或神经退行性疾病（如阿尔茨海默病）。
• PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF DIABETES MELLITUS AND OTHER METABOLIC DISEASES
  申请人：Colca Gerard R.

  公开号：US20120322728A1

  公开（公告）日：2012-12-20

  The present invention relates to thiazolidinedione analogues and pharmaceutical compositions that are useful for treating and/or preventing diabetes mellitis, optionally in combination with a second treatment. Furthermore, the present invention also provides methods of inducing remission of the symptoms of diabetes mellitis in a patient comprising administering a thiazolidinedione analogue and a GLP-1 agonist.

  本发明涉及噻唑烷二酮类似物和制药组合物，用于治疗和/或预防糖尿病，可选择与第二种治疗方法结合使用。此外，本发明还提供了诱导糖尿病症状缓解的方法，包括给患者服用噻唑烷二酮类似物和GLP-1激动剂。
• US8912335B2
  申请人：——

  公开号：US8912335B2

  公开（公告）日：2014-12-16
• US9126959B2
  申请人：——

  公开号：US9126959B2

  公开（公告）日：2015-09-08
• [EN] PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF DIABETES MELLITUS AND OTHER METABOLIC DISEASES<br/>[FR] THIAZOLIDINE DIONES ÉPARGNANT LES PPAR ET ASSOCIATIONS POUR LE TRAITEMENT DU DIABÈTE SUCRÉ ET D'AUTRES MALADIES MÉTABOLIQUES
  申请人：METABOLIC SOLUTIONS DEV CO

  公开号：WO2011084456A1

  公开（公告）日：2011-07-14

  The present invention relates to thiazolidinedione analogues and pharmaceutical compositions that are useful for treating and/or preventing diabetes mellitis, optionally in combination with a second treatment. Furthermore, the present invention also provides methods of inducing remission of the symptoms of diabetes mellitis in a patient comprising administering a thiazolidinedione analogue and a GLP-1 agonist.