(R)-1,2-bis<(p-tolylsulfonyl)oxy>-4-(methylthio)butane | 126688-39-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-1,2-bis<(p-tolylsulfonyl)oxy>-4-(methylthio)butane
• 英文别名: (R)-4-(Methylthio)-2-(p-toluenesulfonyloxy)-butyl p-Toluenesulfonate；(R)-1,2-bis[(p-tolylsulfonyl)oxy]-4-(methylthio)butane；(R)-4-(Methylthio)-2-(p-toluenesulfonyloxy)butyl p-Toluenesulfonate；[(2R)-2-(4-methylphenyl)sulfonyloxy-4-methylsulfanylbutyl] 4-methylbenzenesulfonate
• CAS: 126688-39-9
• 化学式: C₁₉H₂₄O₆S₃
• 分子量: 444.594
• InChiKey: JKNJCUWMJLLIAL-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  129
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (R)-1,2-bis<(p-tolylsulfonyl)oxy>-4-(methylthio)butane 以 苯 为溶剂， 以38%的产率得到1(R)-methyl-3(R)-<(p-tolylsulfonyl)oxy>thiolanium p-toluenesulfonate
  参考文献：
  名称：

  Synthesis of optically active 3(R)-[(alkylsulfonyl)oxy]thiolanes from 2(R)-hydroxy-4-(methylthio)butanoic acid or D-methionine

  摘要：

  DOI：

  10.1021/jo00298a057
• 作为产物：
  描述：

  ethyl 2(R)-hydroxy-4-(methylthio)butyrate 在 吡啶 、 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 18.0h， 生成 (R)-1,2-bis<(p-tolylsulfonyl)oxy>-4-(methylthio)butane
  参考文献：
  名称：

  Synthesis of optically active 3(R)-[(alkylsulfonyl)oxy]thiolanes from 2(R)-hydroxy-4-(methylthio)butanoic acid or D-methionine

  摘要：

  DOI：

  10.1021/jo00298a057

文献信息

• Process for optically active 3-(methane-sulfonyloxy)thiolane and analogs
  申请人：Pfizer Inc.

  公开号：US04874877A1

  公开（公告）日：1989-10-17

  Intermediates and a stepwise process for the conversion of D-methionine or certain of its derivatives to optically active compounds of the formula ##STR1## wherein R is (C.sub.1 -C.sub.3) alkyl, phenyl or tolyl. The latter compounds are in turn useful as an intermediate in the preparation of penem antibiotic 5R,6S-6-(1R-hydroxyethyl)-2-(1R-oxo-3S-thiolanylthio)-2-penem-3-carboxylic acid and corresponding pharmaceutically acceptable salts and esters.

  D-蛋氨酸或其某些衍生物转化为光学活性化合物的中间体及逐步过程，其中R为C1-C3烷基，苯基或甲苯基。这些化合物又作为制备青霉烯抗生素5R，6S-6-(1R-羟基乙基)-2-(1R-氧代-3S-巯基乙烷硫基)-2-青霉烯-3-羧酸及其相应的药用可接受盐和酯的中间体。
• Process for optically active 3-(methane-sulfonyloxy) thiolane and analogs
  申请人：Pfizer Inc.

  公开号：US04954647A1

  公开（公告）日：1990-09-04

  Intermediates and a stepwise process for the conversion of D-methionine or certain of its derivatives to optically active compounds of the formula ##STR1## wherein R is (C.sub.1 -C.sub.3)alkyl, phenyl or tolyl. The latter compounds are in turn useful as an intermediate in the preparation of penem antibiotic 5R,6S-6-(1R-hydroxyethyl)-2-(1R-oxo-3S-thiolanylthio)-2-penem-3-carboxylic acid and corresponding pharmaceutically acceptable salts and esters.

  将D-蛋氨酸或其某些衍生物转化为光学活性化合物的中间体和逐步过程，其中化合物的化学式为##STR1## 其中R为(C.sub.1-C.sub.3)烷基，苯基或甲苯基。这些化合物反过来又可用作制备青霉烷类抗生素5R,6S-6-(1R-羟乙基)-2-(1R-氧代-3S-硫代基硫基)-2-青霉烷-3-羧酸及相应的药用盐和酯的中间体。
• Process for optically active 3-(methane-sulfonyloxy)thioland and analogs
  申请人：PFIZER INC.

  公开号：EP0338735A1

  公开（公告）日：1989-10-25

  Intermediates and a stepwise process for the conversion of D-methionine or certain of its deriva­tives to optically active compounds of the formula wherein R is (C₁-C₃)alkyl, phenyl or tolyl. The latter compounds are in turn useful as an intermediate in the preparation of penem antibiotic 5R,6S-6-(1R-hydroxy­ethyl)-2-(1R-oxo-3S-thiolanylthio)-2-penem-3-carboxylic acid and corresponding pharmaceutically acceptable salts and esters.

  将 D-蛋氨酸或其某些衍生物转化为光学活性式化合物的中间体和分步工艺 其中 R 是 (C₁-C₃)烷基、苯基或甲苯基。后一种化合物又可作为制备青霉烯抗生素 5R,6S-6-(1R-羟乙基)-2-(1R-氧代-3S-硫巯基)-2-青霉烯-3-羧酸及相应的药学上可接受的盐和酯的中间体。
• Substituted benzimidazole and indazole derivatives, processes for their preparation and their use as herbicides
  申请人：ZENECA LIMITED

  公开号：EP0448206A2

  公开（公告）日：1991-09-25

  A herbicidal compound of formula (I) : or N-oxide or quaternised derivative thereof; in which the dotted lines indicate the presence of two double bonds arranged so as to form a fused hetero-aromatic ring system; Ar is an optionally substituted aryl or heterocyclic ring system; W is 0 or NR1 where R1 is H or lower alkyl; A, B, D are independently selected from N, NR2, N-E, CR6, C-E or C(R6)E; wherein E is: provided 2 of A, B and D are N, NR2 or N-E and at least one of A, B or D carries a group E; where R2 is H, OR7, CN, COOR8, alkyl or haloalkyl; R3 and R4 are independently selected from H, optionally substituted alkyl, alkenyl or alkynyl, halogen, NR9R10, or R3 and R4 together with the carbon to which they are attached form an optionally substituted alkenyl or cycloalkyl group; R5 is CO2R11, CN, COR11, CH2OR11, CH(OH)R", CH(OR11)R12, CSNH2, COSR11, CSOR", CONHSO2R11, CONR13R14, CONHNR13R14, CONHN+R13R14R15 Y-, CO2-M+ or COON=CR13R14; X is (CH2)n, CH=CH, CH(OR16)CH2 or COCHz; where n is 0, 1 or 2; M is an agriculturally acceptable cation; Y- is an agriculturally acceptable anion; R6 is H, halogen, OR7, CN, COOR8, alkyl or haloalkyl; R7 and R8 are independently H or lower alkyl; R11, R12 and R16 are independently selected from H or an optionally substituted alkyl, alkenyl, alkynyl or aryl group; and R9, R10, R13, R14 and R15 are independently selected from H or an optionally substituted alkyl, alkenyl, alkynyl or aryl group or any two of R9, R10, R13, R14 and R15 together with the atom to which they are attached form a cycloalkyl or heterocyclic ring providing that the compound is other than 5-(2,4-dichlorophenoxy)indazol-1- ylacetic acid or its methyl ester. Process for the preparation of these compounds and compositions containing them are also described.

  式(I)的除草化合物： 或其 N-氧化物或季铵化衍生物； 其中虚线表示存在两个双键，排列成一个融合的杂芳香环系统； Ar 是任选取代的芳环或杂环系统； W 是 0 或 NR1 其中 R1 是 H 或低级烷基； A、B、D 独立选自 N、NR2、N-E、CR6、C-E 或 C(R6)E； 其中 E 是 A、B 和 D 中有 2 个是 N、NR2 或 N-E，且 A、B 或 D 中至少有一个带有基团 E； 其中 R2 为 H、OR7、CN、COOR8、烷基或卤代烷基； R3 和 R4 独立选自 H、任选取代的烷基、烯基或炔基、卤素、NR9R10，或 R3 和 R4 与它们所连接的碳一起形成任选取代的烯基或环烷基； R5 是 CO2R11、CN、COR11、CH2OR11、CH(OH)R"、CH(OR11)R12、CSNH2、COSR11、CSOR"、CONHSO2R11、CONR13R14、CONHNR13R14、CONHN+R13R14R15 Y-、CO2-M+ 或 COON=CR13R14； X 是 (CH2)n、CH=CH、CH(OR16)CH2 或 COCHz； 其中 n 为 0、1 或 2； M 是农业上可接受的阳离子； Y- 是农业上可接受的阴离子； R6 是 H、卤素、OR7、CN、COOR8、烷基或卤代烷基； R7 和 R8 独立地为 H 或低级烷基； R11、R12 和 R16 独立选自 H 或任选取代的烷基、烯基、炔基或芳基；以及 R9、R10、R13、R14 和 R15 独立选自 H 或任选取代的烷基、烯基、炔基或芳基，或 R9、R10、R13、R14 和 R15 中的任意两个与它们所连接的原子一起形成环烷基或杂环，条件是该化合物不是 5-(2,4-二氯苯氧基)吲唑-1-基乙酸或其甲酯。 此外，还介绍了这些化合物的制备工艺和含有这些化合物的组合物。
• URBAN, FRANK J.
  作者：URBAN, FRANK J.

  DOI：——

  日期：——