3-Ethylpyrazine-2-carboxylic acid | 1541036-91-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-Ethylpyrazine-2-carboxylic acid
• CAS: 1541036-91-2
• 化学式: C₇H₈N₂O₂
• 分子量: 152.15
• InChiKey: VRKSXGOUYTZDFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  63.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 4-phenylpiperidines, their preparation and use
  申请人：The Trustees of Columbia University in the City of New York

  公开号：US11028098B2

  公开（公告）日：2021-06-08

  The present invention provide a compound having the structure: (structurally represented) wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is H, OH, or halogen; B is a substituted or unsubstituted heterobicycle, pyridazine, pyrazole, pyrazine, thiadiazole, or triazole, wherein the heterocycle is other than chloro substituted indole; and the pyrazole, when substituted, is substituted with other than trifluoromethyl, or a pharmaceutically acceptable salt thereof.

  本发明提供一种具有以下结构的化合物：(结构表示）其中R1、R2、R3、R4和R5各自独立地为H、卤素、CF3或C1-C4烷基；R6为H、OH或卤素；B为取代或未取代的杂环、哒嗪、吡唑、吡嗪、噻二唑或三唑，其中杂环为氯取代的吲哚以外的杂环；吡唑被取代时为三氟甲基以外的取代基，或其药学上可接受的盐。
• 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE
  申请人：The Trustees of Columbia University in the City of New York

  公开号：US20190031681A1

  公开（公告）日：2019-01-31

  The present invention provide a compound having the structure: (structurally represented) wherein R 1 , R 2 , R 3 , R 4 , and R 5 are each independently H, halogen, CF 3 or C 1 -C 4 alkyl; R 6 is H, OH, or halogen; B is a substituted or unsubstituted heterobicycle, pyridazine, pyrazole, pyrazine, thiadiazole, or triazole, wherein the heterocycle is other than chloro substituted indole; and the pyrazole, when substituted, is substituted with other than trifluoromethyl, or a pharmaceutically acceptable salt thereof.
• US9944644B2
  申请人：——

  公开号：US9944644B2

  公开（公告）日：2018-04-17
• [EN] COMPOUNDS AND THERAPEUTIC USE THEREOF<br/>[FR] COMPOSÉS ET LEUR UTILISATION THÉRAPEUTIQUE
  申请人：MYRIAD GENETICS INC

  公开号：WO2009073818A1

  公开（公告）日：2009-06-11

  The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection.