2-methyl-1H-benzoimidazole 3-oxide | 16007-52-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-methyl-1H-benzoimidazole 3-oxide
• 英文别名: 2-methyl-1H-benzoimidazole 3-oxide；2-methyl-3H-benzimidazole-1-oxide；2-Methyl-3H-benzimidazol-1-oxid；2-Methyl-benzimidazol-3-oxid
• CAS: 16007-52-6
• 化学式: C₈H₈N₂O
• 分子量: 148.164
• InChiKey: VXOBWUFJHMZZSJ-UHFFFAOYSA-N

物化性质

• 沸点：
  351.0±25.0 °C(Predicted)
• 密度：
  1.27±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.11
• 重原子数：
  11.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  42.73
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  2-methyl-1H-benzoimidazole 3-oxide 、 氨 、 iron(II) sulfate 生成 2-甲基苯并咪唑
  参考文献：
  名称：

  Do the Risks and Consequences of Hospitalized Fall Injuries Among Older Adults in California Vary by Type of Fall?

  摘要：

  Background. Research on fall injuries in older persons generally does not examine different types of falls separately. (The main types are same level, from one level to another, and on or from stairs and steps.) There is no a priori reason to believe that various types of falls have similar demographic risk factors and consequences. Therefore, we examined patterns in types of falls, place of falls, and consequences of fall injuries as Californians move through their later decides.Methods. We analyzed all computerized patient discharge records for all adults 20 years and over hospitalized with a fail as the principal external cause of injury in California nonfederal acute care hospitals, from 1995 through 1997 (N = 242,166). Older-adult age groups were compared with all younger adults. Place of fill, hospital charges, and disposition at discharge were analyzed by type of fall.Results. The three main types of fall injury increase with age, but each type shows variation by age and sex. Women have the highest rates for the main types but not for the less common types. Hospitalized falls vary by place of fill. Mean hospital charges ($17,086) vary by type of fall, with falls from one level to another having the largest mean hospital charge ($19,632). Disposition at discharge does not vary by type of fall.Conclusions. We found significant variation in demographic factors, place of fall, and mean hospital charges for falling by type of fall, suggesting that future research should focus on individual types of falls rather thin on aggregated falls.

  DOI：

  10.1093/gerona/56.11.m686
• 作为产物：
  描述：

  2-硝基乙酰苯胺 在 ammonium sulfide 作用下， 生成 2-methyl-1H-benzoimidazole 3-oxide
  参考文献：
  名称：

  Do the Risks and Consequences of Hospitalized Fall Injuries Among Older Adults in California Vary by Type of Fall?

  摘要：

  Background. Research on fall injuries in older persons generally does not examine different types of falls separately. (The main types are same level, from one level to another, and on or from stairs and steps.) There is no a priori reason to believe that various types of falls have similar demographic risk factors and consequences. Therefore, we examined patterns in types of falls, place of falls, and consequences of fall injuries as Californians move through their later decides.Methods. We analyzed all computerized patient discharge records for all adults 20 years and over hospitalized with a fail as the principal external cause of injury in California nonfederal acute care hospitals, from 1995 through 1997 (N = 242,166). Older-adult age groups were compared with all younger adults. Place of fill, hospital charges, and disposition at discharge were analyzed by type of fall.Results. The three main types of fall injury increase with age, but each type shows variation by age and sex. Women have the highest rates for the main types but not for the less common types. Hospitalized falls vary by place of fill. Mean hospital charges ($17,086) vary by type of fall, with falls from one level to another having the largest mean hospital charge ($19,632). Disposition at discharge does not vary by type of fall.Conclusions. We found significant variation in demographic factors, place of fall, and mean hospital charges for falling by type of fall, suggesting that future research should focus on individual types of falls rather thin on aggregated falls.

  DOI：

  10.1093/gerona/56.11.m686

文献信息

• 6-beta(substituted)-(S)-hydroxymethylpenicillanic acids and derivatives
  申请人：Pfizer Inc.

  公开号：US04782050A1

  公开（公告）日：1988-11-01

  Antibacterial penicillins of the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.1 is a heterocyclic group and R is hydrogen, the residue of certian carboxy protecting groups or the residue of an ester group readily hydrolyzable in vivo having activity against resistant organisms.

  公式为##STR1##的抗菌青霉素，或其药学上可接受的盐，其中R.sup.1是杂环基团，R是氢，某些羧保护基团的残基或易在体内水解的酯基团的残基，具有对抗耐药菌的活性。
• Fries; Reitz, Justus Liebigs Annalen der Chemie, 1937, vol. 527, p. 38,50
  作者：Fries、Reitz

  DOI：——

  日期：——
• LATHAM D. W. S.; METH-COHN O.; SUSCHITZKY H.; HERBERT J. A. L., J. CHEM. SOC. PERKIN TRANS., PART 1 <JCPK-BH>, 1977, NO 5, 470-478
  作者：LATHAM D. W. S.、 METH-COHN O.、 SUSCHITZKY H.、 HERBERT J. A. L.

  DOI：——

  日期：——
• 6-Beta(substituted)-(S)-hydroxymethylpenicillanic acids and derivatives thereof
  申请人：PFIZER INC.

  公开号：EP0276942B1

  公开（公告）日：1992-04-01
• US4782050A
  申请人：——

  公开号：US4782050A

  公开（公告）日：1988-11-01