5-(2-{[2-(Bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-acetylamino)-2-hydroxy-benzoic acid | 794488-25-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(2-{[2-(Bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-acetylamino)-2-hydroxy-benzoic acid
• CAS: 794488-25-8
• 化学式: C₁₇H₂₁N₃O₁₀
• 分子量: 427.368
• InChiKey: NOBRRZRAWTZUOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.11
• 重原子数：
  30.0
• 可旋转键数：
  13.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  205.01
• 氢给体数：
  6.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  europium(III) chloride hexahydrate 、 5-(2-{[2-(Bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-acetylamino)-2-hydroxy-benzoic acid 以 水 为溶剂， 以96%的产率得到
  参考文献：
  名称：

  An Investigation on the Analytical Potential of Polymerized Liposomes Bound to Lanthanide Ions for Protein Analysis

  摘要：

  We present a promising approach to protein sensing based on Eu3+ ions incorporated into polymerized liposomes. The sensitization of Eu3+ is accomplished with 5-aminosalicylic acid, which provides energy transfer for a stable reference signal and a wide wavelength excitation range free from protein interference. The lipophilic character of polymerized liposomes provides the appropriate platform for protein interaction with the lanthanide ion. Quantitative analysis is based on the linear relationship between the luminescence signal of Eu3+ and protein concentration. Because no spectral shift of the lanthanide luminescence is observed upon protein interaction, qualitative analysis is based on the luminescence lifetime of polymerized liposomes. This parameter, which changes significantly upon protein - liposome interaction, follows a well-behaved single-exponential decay that might be useful for protein identification.

  DOI：

  10.1021/ja048963b
• 作为产物：
  描述：

  5-(2-{[2-(Bis-ethoxycarbonylmethyl-amino)-ethyl]-ethoxycarbonylmethyl-amino}-acetylamino)-2-hydroxy-benzoic acid 在 lithium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 15.0h， 以69%的产率得到5-(2-{[2-(Bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-acetylamino)-2-hydroxy-benzoic acid
  参考文献：
  名称：

  An Investigation on the Analytical Potential of Polymerized Liposomes Bound to Lanthanide Ions for Protein Analysis

  摘要：

  We present a promising approach to protein sensing based on Eu3+ ions incorporated into polymerized liposomes. The sensitization of Eu3+ is accomplished with 5-aminosalicylic acid, which provides energy transfer for a stable reference signal and a wide wavelength excitation range free from protein interference. The lipophilic character of polymerized liposomes provides the appropriate platform for protein interaction with the lanthanide ion. Quantitative analysis is based on the linear relationship between the luminescence signal of Eu3+ and protein concentration. Because no spectral shift of the lanthanide luminescence is observed upon protein interaction, qualitative analysis is based on the luminescence lifetime of polymerized liposomes. This parameter, which changes significantly upon protein - liposome interaction, follows a well-behaved single-exponential decay that might be useful for protein identification.

  DOI：

  10.1021/ja048963b