methyl-2-(tosyloxy)butyrate | 118921-64-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl-2-(tosyloxy)butyrate
• 英文别名: methyl 2-tosyloxybutyrate；Methyl 2-(tosyloxy)butanoate；methyl 2-(4-methylphenyl)sulfonyloxybutanoate
• CAS: 118921-64-5
• 化学式: C₁₂H₁₆O₅S
• 分子量: 272.322
• InChiKey: XPUBUZQRGXUOMR-UHFFFAOYSA-N

物化性质

• 沸点：
  384.3±25.0 °C(Predicted)
• 密度：
  1.217±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  78
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  羟基甲苯磺酰碘苯 、 (1-methoxybut-1-enyloxy)trimethylsilane 以 二氯甲烷 为溶剂， 反应 2.0h， 以65%的产率得到methyl-2-(tosyloxy)butyrate
  参考文献：
  名称：

  Reaction of [hydroxy(tosyloxy)iodo]benzene and [hydroxy(mesyloxy)iodo]benzene with trimethylsilyl enol ethers. A new general method for .alpha.-sulfonyloxylation of carbonyl compounds

  摘要：

  DOI：

  10.1021/jo00266a020

文献信息

• GLYCOSAMINOGLYCAN DERIVATIVE AND METHOD FOR PRODUCING SAME
  申请人：SEIKAGAKU CORPORATION

  公开号：US20160151506A1

  公开（公告）日：2016-06-02

  The present invention provides a glycosaminoglycan derivative in which a group derived from glycosaminoglycan and a group derived from a physiologically active substance having at least one of a carboxy group and a hydroxy group are coupled by covalent bond with a spacer therebetween, in which the spacer is selected in accordance with the decomposition rate of the covalent bond to the group derived from the physiologically active substance.

  本发明提供了一种糖氨基聚糖衍生物，其中从糖氨基聚糖衍生的基团和从至少具有羧基或羟基之一的生理活性物质衍生的基团通过之间的间隔物以共价键偶联，其中该间隔物根据从生理活性物质衍生的基团的共价键的分解速率进行选择。
• Functionalization of carboxylic anhydrides at α-carbon with hypervalent iodine reagents: one-pot conversion of anhydrides to 2-sulfonyloxycarboxylate esters
  作者：Jeffrey M Goff、Michael W Justik、Gerald F Koser

  DOI：10.1016/s0040-4039(01)01028-0

  日期：2001.8

  The treatment of carboxylic anhydrides with iodine(III) sulfonate reagents at ca. 100°C and esterification of the reaction mixtures with MeOH/TsOH·H2O affords 2-sulfonyloxycarboxylate esters. This is consistent with enolic behavior in the anhydrides.

  用碘（III）磺酸盐试剂在约75℃下处理羧酸酐。100℃下，将反应混合物用MeOH / TsOH·H 2 O酯化，得到2-磺酰氧基羧酸酯。这与酸酐中的烯醇行为一致。
• MORIARTY, ROBERT M.;PENMASTA, RAJU;AWASTHI, ALOK K.;EPA, W. RUWAN;PRAKASH+, J. ORG. CHEM., 54,(1989) N, C. 1101-1104
  作者：MORIARTY, ROBERT M.、PENMASTA, RAJU、AWASTHI, ALOK K.、EPA, W. RUWAN、PRAKASH+

  DOI：——

  日期：——
• Reaction of [hydroxy(tosyloxy)iodo]benzene and [hydroxy(mesyloxy)iodo]benzene with trimethylsilyl enol ethers. A new general method for .alpha.-sulfonyloxylation of carbonyl compounds
  作者：Robert M. Moriarty、Raju Penmasta、Alok K. Awasthi、W. Ruwan Epa、Indra Prakash

  DOI：10.1021/jo00266a020

  日期：1989.3