| 903519-40-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• CAS: 903519-40-4
• 化学式: C₃₀H₄₄O₆
• 分子量: 500.676
• InChiKey: DIGRAXMTVGQRHP-FMIBHVMRSA-N

反应信息

• 作为产物：
  描述：

  在 VinP₄ polyketide synthase thioesterase domain 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 以43%的产率得到
  参考文献：
  名称：

  Potent Oligomerization and Macrocyclization Activity of the Thioesterase Domain of Vicenistatin Polyketide Synthase

  摘要：

  The thioesterase domain of the polyketide synthase involved in the biosynthesis of the 20-membered macrolactam antibiotic vicenistatin (VinTE) was found to catalyze oligomerization and macrocyclization of omega-hydroxy fatty acid ethyl esters to afford 17-28-membered macrocyclic lactones. The ring sizes of the macrocycles appear to be limited to the more moderate sizes because of the space limitation of the active site of VinTE. It was also verified that the initially formed linear dimer is first released from the active site of VinTE and then is recognized again by VinTE prior to its transformation to the cyclic dimer.

  DOI：

  10.1055/s-0031-1290385