isopropyl 2-(2,6-difluorophenyl)-4-(2-chloro-4-fluorophenyl)-6-methyl-1,4-dihydro-pyrimidin-5-carboxylate | 1006047-40-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: isopropyl 2-(2,6-difluorophenyl)-4-(2-chloro-4-fluorophenyl)-6-methyl-1,4-dihydro-pyrimidin-5-carboxylate
• 英文别名: Propan-2-yl 4-(2-chloro-4-fluorophenyl)-2-(2,6-difluorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate
• CAS: 1006047-40-0
• 化学式: C₂₁H₁₈ClF₃N₂O₂
• 分子量: 422.834
• InChiKey: ZODHPIHOIPIEFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Dihydropyrimidine Compounds and Their Uses in Preparation of Medicaments for Treating and Preventing Antiviral Diseases
  申请人：Li Song

  公开号：US20100087448A1

  公开（公告）日：2010-04-08

  The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, to a process for preparing the compound of formula (I), and to use of the compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof as a medicament, in particular as a medicament for the treatment and prevention of type B hepatitis.

  本发明涉及一种式（I）的化合物或其药学上可接受的盐或水合物，制备该式（I）化合物的方法，以及将该式（I）的化合物或其药学上可接受的盐或水合物用作药物，特别是用作治疗和预防乙型肝炎的药物。
• DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USES IN PREPARATION OF MEDICAMENTS FOR TREATING AND PREVENTING ANTIVIRAL DISEASES
  申请人：Beijing Molecule Science and Technology Co., Ltd.

  公开号：EP2039686A1

  公开（公告）日：2009-03-25

  The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, to a process for preparing the compound of formula (I), and to use of the compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof as a medicament, in particular as a medicament for the treatment and prevention of type B hepatitis.

  本发明涉及一种式（I）化合物或其药学上可接受的盐或水合物，涉及一种制备式（I）化合物的工艺，还涉及将式（I）化合物或其药学上可接受的盐或水合物用作药物，特别是用作治疗和预防乙型肝炎的药物。
• Dihydropyrimidine compounds and use thereof for the treatment of viral diseases
  申请人：Beijing Molecule Science and Technology Co., Ltd.

  公开号：EP2336115A1

  公开（公告）日：2011-06-22

  The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, to a process for preparing the compound of formula (I), and to use of the compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof as a medicament, in particular as a medicament for the treatment and prevention of type B hepatitis.

  本发明涉及一种式（I）化合物或其药学上可接受的盐或水合物，涉及一种制备式（I）化合物的工艺，还涉及将式（I）化合物或其药学上可接受的盐或水合物用作药物，特别是用作治疗和预防乙型肝炎的药物。
• US8168642B2
  申请人：——

  公开号：US8168642B2

  公开（公告）日：2012-05-01