N-(5,6,7,8-tetrahydronaphthalen-2-yl)benzamide | 109394-58-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: N-(5,6,7,8-tetrahydronaphthalen-2-yl)benzamide
• 英文别名: N-(5,6,7,8-tetrahydro-[2]naphthyl)-benzamide；N-(5,6,7,8-Tetrahydro-[2]naphthyl)-benzamid；6-Benzamino-tetralin；Benzoyl-(ar.-tetrahydro-β-naphthylamin)
• CAS: 109394-58-3
• 化学式: C₁₇H₁₇NO
• 分子量: 251.328
• InChiKey: LFRGQFRXYRCPHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.82
• 重原子数：
  19.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  29.1
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  N-2-萘基苯甲酰胺 在 nickel kieselguhr 、 氢气 、 萘烷 作用下， 170.0 ℃ 、3.04 MPa 条件下， 生成 N-(5,6,7,8-tetrahydronaphthalen-2-yl)benzamide
  参考文献：
  名称：

  DE479401

  摘要：

  公开号：

文献信息

• Efficient conversion of acids and esters to amides and transamidation of primary amides using OSU-6
  作者：Baskar Nammalwar、Nagendra Prasad Muddala、Field M. Watts、Richard A. Bunce

  DOI：10.1016/j.tet.2015.10.016

  日期：2015.12

  with strong Bronsted acid properties, has been used to promote the high-yield conversion of carboxylic acids and esters to carboxamides as well as transamidations of primary amides in a one-pot solventless approach. A metal-free heterogeneous catalyst that promotes all of these processes has not been previously reported. OSU-6 enables these transformations to proceed in shorter times and at lower temperatures

  OSU-6，具有强布朗斯台德酸性质的MCM-41型六角孔二氧化硅，已被用来促进的羧酸和酯的高产转化为羧酰胺，以及在单罐无溶剂方法伯酰胺的transamidations。先前尚未报道可促进所有这些过程的无金属非均相催化剂。OSU-6使这些转化能够在更短的时间和更低的温度下针对多种基材进行。一个附加的好处是，该催化剂可以回收和不活动的显著损失重复使用多次。
• <i>para</i>-Selective CH Amidation of Simple Arenes with Nitriles
  作者：Shi-Kai Xiang、Jin-Mei Li、He Huang、Chun Feng、Hai-Liang Ni、Xiao-Zhen Chen、Bi-Qin Wang、Ke-Qing Zhao、Ping Hu、Carl Redshaw

  DOI：10.1002/adsc.201500651

  日期：2015.11.16

  A para-selective CH amidation of simple arenes with nitriles has been developed. By increasing the amount of arenes, a further meta-selective CH arylation of the produced amides occurred. Both steric and electronic effects are utilized to control the selectivity, resulting in only para-selective amidation products. The readily available nitriles as amidation reagents instead of amides makes the synthesis

  一对简单的芳烃与腈-选择性CH酰胺化已经研制成功。通过增加芳烃的量，进一步元所产生的酰胺-选择性CH芳基化发生。利用空间效应和电子效应来控制选择性，仅产生对位选择性酰胺化产物。作为酰胺化试剂而不是酰胺的现成腈使N-芳基酰胺的合成更容易进行。
• Practical povidone iodine catalyzed transamidation from primary amides and amines
  作者：Jian Wang、Jiangmeng Ren、Yun-Peng Zhu、Xue-Qin Sun、Peng-Fei Hu、Xin Mu、Bu-Bing Zeng

  DOI：10.1016/j.tetlet.2022.154312

  日期：2023.2

  Non-harmful Povidone iodine (PVP-I) was applied in the transamidation to gain N-substituted amides from various primary amides and amines. Diverse aromatic, heterocyclic and aliphatic primary amides/amines were applied in our developed method and more than 45 N-substituted amides were obtained with excellent yields in most cases. Several drugs such as Melatonin and Efaproxiral were successfully acquired

  将无害的聚维酮碘 (PVP-I) 应用于转酰胺基反应，以从各种伯酰胺和胺中获得N-取代的酰胺。在我们开发的方法中应用了多种芳香族、杂环族和脂肪族伯酰胺/胺，在大多数情况下以优异的收率获得了超过 45 种 N-取代的酰胺。成功获得了褪黑激素和依法普西拉等几种药物，其性能优于先前报道的结果。
• Scharwin, Chemische Berichte, 1902, vol. 35, p. 2511
  作者：Scharwin

  DOI：——

  日期：——
• Lindner; Djulgerowa; Mayr, Monatshefte fur Chemie, 1923, vol. 44, p. 339
  作者：Lindner、Djulgerowa、Mayr

  DOI：——

  日期：——