溴芬酸钠杂质23 | 71969-36-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 溴芬酸钠杂质23
• 英文名称: (2-Amino-3-methyl-phenyl)-(4-bromo-phenyl)-methanone
• 英文别名: (2-Amino-3-methylphenyl)(4-bromophenyl)methanone；(2-amino-3-methylphenyl)-(4-bromophenyl)methanone
• CAS: 71969-36-3
• 化学式: C₁₄H₁₂BrNO
• 分子量: 290.159
• InChiKey: RJDHAOMNCJWTTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  溴芬酸钠杂质23 在 一水合肼 、 zinc(II) chloride 作用下， 生成
  参考文献：
  名称：

  DE2903709

  摘要：

  公开号：

文献信息

• Acetic acid derivatives of 3-aryl-2,1-benzisoxazole and esters and
  申请人：A. H. Robins Company, Inc.

  公开号：US04898874A1

  公开（公告）日：1990-02-06

  3-Aryl-2,1-benzisoxazole compounds having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen or methyl; R.sup.3 and R.sup.4 are hydroxyl, loweralkoxy, amino or --OM wherein M is a pharmaceutically acceptable cation; X is hydrogen, halogen, loweralkyl or nitro; Y is selected from hydrogen, halogen, loweralkyl, loweralkoxy, nitro or trifluoromethyl; n and p are zero or one with the proviso that either n or p must be one are disclosed, having anti-inflammatory activity and novel intermediates in the preparation thereof.

  具有下列式子的3-芳基-2,1-苯并异噁唑化合物：##STR1## 其中R.sup.1和R.sup.2是氢或甲基；R.sup.3和R.sup.4是羟基、低碳氧基、氨基或--OM，其中M是一种药用可接受的阳离子；X是氢、卤素、低碳基或硝基；Y是选自氢、卤素、低碳基、低碳氧基、硝基或三氟甲基；n和p为零或一，但必须满足n或p之一必须为一，具有抗炎活性和制备中的新型中间体。
• NITROSATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE
  申请人：EARL Richard A.

  公开号：US20100093708A1

  公开（公告）日：2010-04-15

  The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.

  该发明描述了新型的亚硝基化非甾体抗炎药（NSAIDs）及其药学上可接受的盐，以及包含至少一种亚硝基化NSAID的新型组合物，可选地包含至少一种捐赠、转移或释放一氧化氮、刺激内源性一氧化氮合成、提高内源性内皮源性松弛因子水平或是一氧化氮合酶底物的化合物，以及/或至少一种治疗剂。该发明还提供包含至少一种亚硝基化NSAID和至少一种捐赠、转移或释放一氧化氮、提高内源性内皮源性松弛因子水平、刺激内源性一氧化氮合成或是一氧化氮合酶底物和/或至少一种治疗剂的新型组合物。该发明还提供包含至少一种亚硝基化NSAID，可选地包括至少一种一氧化氮供体和/或至少一种治疗剂的新型套件。该发明还提供用于治疗炎症、疼痛和发热的方法；用于治疗胃肠道疾病的方法；用于促进伤口愈合的方法；用于治疗和/或预防由非甾体抗炎化合物使用引起的胃肠道、肾脏和/或呼吸道毒性的方法；用于治疗炎症性疾病状态和/或疾病的方法；以及用于治疗和/或预防眼科疾病和/或疾病的方法。
• WALSH, DAVID A.;UWAYDAH, IBRAHIM M.
  作者：WALSH, DAVID A.、UWAYDAH, IBRAHIM M.

  DOI：——

  日期：——
• Drugs for the arthritis treatment
  申请人：Del Soldato Piero

  公开号：US20070010458A1

  公开（公告）日：2007-01-11

  Antiinflammatory and/or antiinflammatory/analgesic compounds having the following general formula: A-(B) b0 —(C) c0 —N(O) s (I) or salts thereof, wherein: A contains the radical of a non steroidal antiinflammatory or non steroidal antiinflammatory/analgesic drug, B and C are bivalent linking groups, are used in the arthritis therapy.
• ORGANIC NITRIC OXIDE DONOR SALTS OF NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE
  申请人：Garvey David S.

  公开号：US20090048219A1

  公开（公告）日：2009-02-19

  The invention describes novel organic nitric oxide enhancing salts of nonsteroidal antiinflammatory drugs (NSAIDs) and novel compositions comprising at least one organic nitric oxide enhancing salt of an NSAID, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides novel compositions and kits comprising at least one organic nitric oxide enhancing salt of an NSAID, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating inflammation, pain and fever; (b) treating gastrointestinal disorders; (c) facilitating wound healing; (d) treating gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; (e) treating inflammatory disease states and/or disorders; (f) treating ophthalmic disorders; (h) treating peripheral vascular diseases; (i) treating diseases resulting from oxidative stress; (j) treating endothelial dysfunctions; and (k) treating diseases caused by endothelial dysfunctions. The organic nitric oxide enhancing compounds that form salts with the NSAIDs are organic nitrates, organic nitrites, nitrosothiols, thionitrites, thionitrates, NONOates, heterocyclic nitric oxide donors and/or nitroxides. The heterocyclic nitric oxide donors are furoxans, sydnonimines, oxatriazole-5-ones and/or oxatriazole-5-imines.