1-(2,3-dimethoxy-phenyl)-ethanone oxime | 23997-79-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2,3-dimethoxy-phenyl)-ethanone oxime
• 英文别名: 1-(2,3-Dimethoxy-phenyl)-aethanon-oxim；N-[1-(2,3-dimethoxyphenyl)ethylidene]hydroxylamine
• CAS: 23997-79-7
• 化学式: C₁₀H₁₃NO₃
• 分子量: 195.218
• InChiKey: HZTRZKNQGLEYRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  51
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(2,3-二甲氧基苯基)-1-乙醇 在 chromium(III) oxide 、 sodium hydroxide 、 乙醇 、 硫酸 作用下， 生成 1-(2,3-dimethoxy-phenyl)-ethanone oxime
  参考文献：
  名称：

  v. Krannichfeldt, Chemische Berichte, 1913, vol. 46, p. 4019

  摘要：

  DOI：

文献信息

• Dexamethasone prophylaxis of nausea and vomiting after epidural morphine for post-Cesarean analgesia
  作者：Jhi-Joung Wang、Shung-Tai Ho、Chih-Shung Wong、Jann-Inn Tzeng、Hang-Seng Liu、Luo-Ping Ger

  DOI：10.1007/bf03019733

  日期：2001.2

  Purpose: To determine the minimum effective dose of dexamethasone in preventing nausea and vomiting associated with epidural morphine for post-Cesarean analgesia.Method: One hundred and eighty parturients (n=45 in each of four groups) requiring epidural morphine for post Cesarean analgesia were enrolled in this randomized, double blinded, placebo-controlled study. At the end of surgery, parturients received either dexamethasone, at doses of 10 mg, 5 mg, 2.5 mg, or saline iv. Three milligrams epidural morphine were given to all parturients for postoperative analgesia, The incidence of PONV and side effects were estimated for 24 hr after delivery by blinded, trained nurse anesthetists.Results: Parturients who received dexamethasone, either 10 mg or 5 mg were different from those who received saline alone in the following parameters: the total incidence of nausea and vomiting, incidence of > 4 vomiting episodes, number the of parturients requiring rescue antiemetics, and the total number of parturients with no vomiting and/or no antiemetic medication (P < 0.05 to P < 0.01 ), The differences between dexamethasone 10 mg and 5 mg were not significant. Dexamethasone 2.5 mg was partially effective.Conclusion: Dexamethasone, 5 mg iv, is suggested as the minimum effective dose in preventing nausea and vomiting associated with epidural morphine for post-Cesarean analgesia.