4-[2-(3-chloro-phenyl)-ethyl]-1H-imidazole | 1033822-44-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[2-(3-chloro-phenyl)-ethyl]-1H-imidazole
• 英文别名: 5-[2-(3-chlorophenyl)ethyl]-1H-imidazole
• CAS: 1033822-44-4
• 化学式: C₁₁H₁₁ClN₂
• 分子量: 206.675
• InChiKey: TYLVEKJQHUHFEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• IMIDAZOLE DERIVATIVES
  申请人：Galley Guido

  公开号：US20080146523A1

  公开（公告）日：2008-06-19

  The invention relates to imidazole derivatives which have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1. The invention also relates to a pharmaceutically-suitable acid-addition salt of the above compound. The invention further relates to a composition comprising an imidazole derivative as described above, or a pharmaceutically-suitable acid-addition salt thereof, and to processes for preparing such compounds.

  这项发明涉及对咪唑衍生物的研究，这些衍生物与微量胺相关受体（TAARs）有很好的亲和力，特别是对于TAAR1。该发明还涉及上述化合物的药用适宜的酸盐。该发明还涉及一种包含上述咪唑衍生物或其药用适宜的酸盐的组合物，以及制备这些化合物的方法。
• Substituted imidazoles, their preparation and pharmaceutical compositions containing the same
  申请人：Farmos-Yhtyma Oy

  公开号：EP0034473A2

  公开（公告）日：1981-08-26

  The invention provides compounds of the formula: wherein each of R1, R2 and R3, which can be the same or different is hydrogen, chloro, bromo, fluoro, methyl, ethyl, methoxv, amino, hydroxy or nitro; R4 is hydrogen or alkyl of 1 to 7 carbon atoms; X is (R5 is hydrogen or hydroxy) and n is 1-4; and their non-toxic pharmaceutically acceptable acid addition salts. These compounds exhibitvaluable pharmacological activity and are useful in the treatment of mammals, especially as anti- hypertensive agents. Furthermore, some of the compounds have proved to possess diuretic, ß-blocking activity and/or antithrombotic activity. The compounds may be made by a variety of methods and may be incorporated in pharmaceutical compositions also comprising a compatible pharmaceutically acceptable carrier.

  本发明提供了如下式的化合物： 其中 R1、R2 和 R3（可以相同或不同）各自是氢、氯、溴、氟、甲基、乙基、甲氧基、氨基、羟基或硝基；R4 是氢或 1 至 7 个碳原子的烷基；X 是 (R5 是氢或羟基）和 n 是 1-4；以及它们的无毒药学上可接受的酸加成盐。这些化合物具有宝贵的药理活性，可用于哺乳动物的治疗，特别是作为抗高血压药物。此外，其中一些化合物已被证明具有利尿、ß-阻断活性和/或抗血栓活性。这些化合物可以通过多种方法制得，并可掺入包含相容的药学上可接受的载体的药物组合物中。
• 4-IMIDAZOLINES AS TAAR'S LIGANDS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2094668A2

  公开（公告）日：2009-09-02
• TRACE AMINE ASSOCIATED RECEPTOR 1 AGONISTS AND PARTIAL AGONISTS FOR PAIN TREATMENT
  申请人：Purdue Pharma LP

  公开号：EP3463359A1

  公开（公告）日：2019-04-10
• US4568686A
  申请人：——

  公开号：US4568686A

  公开（公告）日：1986-02-04