1-(4-chloro-phenyl)-2-piperidino-ethanol | 101263-53-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-chloro-phenyl)-2-piperidino-ethanol
• 英文别名: 1-(4-Chlor-phenyl)-2-piperidino-aethanol；1-(4-Chlorophenyl)-2-piperidino-1-ethanol；1-(4-chlorophenyl)-2-piperidin-1-ylethanol
• CAS: 101263-53-0
• 化学式: C₁₃H₁₈ClNO
• mdl: MFCD11613354
• 分子量: 239.745
• InChiKey: IJHFWDPNDNGBJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.538
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(4-chloro-phenyl)-2-piperidino-ethanol 在 盐酸 、 Yarovenko reagent 作用下， 生成 1-[2-(4-Chloro-phenyl)-2-fluoro-ethyl]-piperidine; hydrochloride
  参考文献：
  名称：

  Charlon; Luu-Duc; Huguet, Farmaco, Edizione Scientifica, 1986, vol. 41, # 8, p. 586 - 596

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(4-chlorophenyl)-2-(piperidin-1-yl)ethanone 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 1-(4-chloro-phenyl)-2-piperidino-ethanol
  参考文献：
  名称：

  Dahlbom; Misiorny, Acta Chemica Scandinavica (1947), 1957, vol. 11, p. 1153,1154

  摘要：

  DOI：

文献信息

• Treatment of diseases involving cyst formation with combinations comprising a PTBR agonist
  申请人：SCIOS INC.

  公开号：EP1607744A2

  公开（公告）日：2005-12-21

  The invention concerns the use of ligands of peripheral-type benzodiazepine receptors (PTBR) in the diagnosis and treatment of diseases involving cyst formation and in particular polycystic kidney disease. The invention further concerns the treatment of hypertension accompanying polycystic kidney disease, and pharmaceutical compositions and articles of manufacture for the treatment of diagnosis of the target disease or condition.

  本发明涉及外周型苯并二氮杂卓受体（PTBR）配体在诊断和治疗涉及囊肿形成的疾病，特别是多囊肾疾病中的应用。本发明还涉及伴随多囊肾病的高血压的治疗，以及用于治疗诊断目标疾病或病症的药物组合物和制造品。
• Treatment of diseases involving cyst formation
  申请人：——

  公开号：US20030008864A1

  公开（公告）日：2003-01-09

  The invention concerns the use of ligands of peripheral-type benzodiazepine receptors (PTBR) in the diagnosis and treatment of diseases involving cyst formation and in particular polycystic kidney disease. The invention further concerns the treatment of hypertension accompanying polycystic kidney disease, and pharmaceutical compositions and articles of manufacture for the treatment or diagnosis of the target disease or condition.

  本发明涉及外周型苯并二氮杂卓受体（PTBR）配体在诊断和治疗涉及囊肿形成的疾病，特别是多囊肾疾病中的应用。本发明还涉及伴随多囊肾病的高血压的治疗，以及用于治疗或诊断目标疾病或病症的药物组合物和制造品。
• Agonists and antagonists of peripheral-type benzodiazepine receptors
  申请人：——

  公开号：US20030032637A1

  公开（公告）日：2003-02-13

  The invention concerns the use of agonists and antagonists of peripheral-type benzodiazepine receptors (PTBR) in the diagnosis and treatment of cardiac hypertrophy and other circulatory conditions. The invention specifically concerns the use of PTBR antagonists in the prevention or treatment of decompensated cardiac hypertrophy and, eventually, heart failure. The invention also concerns the use of PTBR agonists in the management of conditions calling for increased blood flow or cardiac output, including injury or functional compromise of the heart, increased demand for physical exercise, or an acquired or inherited predisposition to cardiac contractile disfunction. Pharmaceutical compositions for the treatment of such conditions and screening methods to identify PTBR agonists and antagonists are also included.

  本发明涉及外周型苯并二氮杂卓受体（PTBR）的激动剂和拮抗剂在诊断和治疗心脏肥大和其他循环系统疾病中的应用。本发明特别涉及 PTBR 拮抗剂在预防或治疗失代偿性心脏肥大以及最终的心力衰竭中的应用。本发明还涉及 PTBR 激动剂在治疗需要增加血流量或心输出量的病症中的应用，包括心脏损伤或功能受损、体育锻炼需求增加或获得性或遗传性心脏收缩功能障碍。此外，还包括用于治疗此类病症的药物组合物以及鉴定 PTBR 激动剂和拮抗剂的筛选方法。
• CHARLON C.; LUU-DUC C., ANN. PHARM. FR., 44,(1986) N 2, 123-132
  作者：CHARLON C.、 LUU-DUC C.

  DOI：——

  日期：——
• Fast and efficient synthesis of 2-(benzyloxy)-N,N-disubtituted-2-phenylethan-1-amines
  作者：Paula S. Rivero-Jerez、Jorge Saavedra-Olavarría、Edwin G. Pérez

  DOI：10.1016/j.tetlet.2023.154609

  日期：2023.7