N-(2-Amino-ethyl)-N-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide | 199998-46-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-(2-Amino-ethyl)-N-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide
• CAS: 199998-46-4
• 化学式: C₂₇H₃₆N₄O₄Si
• 分子量: 508.693
• InChiKey: FVPQPCXMLYJYBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.21
• 重原子数：
  36.0
• 可旋转键数：
  10.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  110.42
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  N-(2-Amino-ethyl)-N-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide 在 四丁基氟化铵 作用下， 生成
  参考文献：
  名称：

  Synthesis and Hybridization Properties of Modified Oligonucleotides with PNA-DNA Dimer Blocks

  摘要：

  Different modified PNA-DNA dimer-analogous synthons (I and II) were synthesized as phosphoramidites. These dimer units were assembled by a 5'-modified deoxythymidine and a modified PNA monomer. These synthons were used in the routine coupling procedure for oligonucleotides. Therefore no PNA coupling chemistry is necessary to synthesize PNA-DNA chimeric oligonucleotides. Various deoxyoligonucleotides were synthesized introducing the dimer blocks I and II at different positions in the sequences. Melting temperatures of the modified oligonucleotides with their complementary DNA analogues were determined.

  DOI：

  10.1080/07328319708006120
• 作为产物：
  描述：

  (2-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester 在 哌啶 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 N-(2-Amino-ethyl)-N-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide
  参考文献：
  名称：

  Synthesis and Hybridization Properties of Modified Oligonucleotides with PNA-DNA Dimer Blocks

  摘要：

  Different modified PNA-DNA dimer-analogous synthons (I and II) were synthesized as phosphoramidites. These dimer units were assembled by a 5'-modified deoxythymidine and a modified PNA monomer. These synthons were used in the routine coupling procedure for oligonucleotides. Therefore no PNA coupling chemistry is necessary to synthesize PNA-DNA chimeric oligonucleotides. Various deoxyoligonucleotides were synthesized introducing the dimer blocks I and II at different positions in the sequences. Melting temperatures of the modified oligonucleotides with their complementary DNA analogues were determined.

  DOI：

  10.1080/07328319708006120