N-isopropyl-2,6-dimethoxyaniline | 253681-15-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-isopropyl-2,6-dimethoxyaniline
• 英文别名: 2,6-dimethoxy-N-propan-2-ylaniline
• CAS: 253681-15-1
• 化学式: C₁₁H₁₇NO₂
• 分子量: 195.261
• InChiKey: MBRVJSZJWLENGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-isopropyl-2,6-dimethoxyaniline 在 三氯化铝 、 PPA 作用下， 以 甲苯 为溶剂， 反应 10.0h， 生成 [2,4-dihydroxy-3-(isopropylamino)phenyl]phenylmethanone
  参考文献：
  名称：

  Synthesis of novel orthoalkylaminophenol derivatives as potent neuroprotective agents in vitro

  摘要：

  A series of orthoalkylaminophenol derivatives was synthesized and tested in vitro with respect to their neuroprotective effect. Some of these compounds exhibited a potent antioxidant activity close to that of standard alpha-tocopherol. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00504-1
• 作为产物：
  描述：

  1,3-二甲氧基-2-硝基苯 在 三乙酰氧基硼氢化钠 、 铁粉 、 溶剂黄146 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 10.0h， 生成 N-isopropyl-2,6-dimethoxyaniline
  参考文献：
  名称：

  Synthesis of novel orthoalkylaminophenol derivatives as potent neuroprotective agents in vitro

  摘要：

  A series of orthoalkylaminophenol derivatives was synthesized and tested in vitro with respect to their neuroprotective effect. Some of these compounds exhibited a potent antioxidant activity close to that of standard alpha-tocopherol. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00504-1

文献信息

• Alkylation of Amines with Alcohols and Amines by a Single Catalyst under Mild Conditions
  作者：Qingzhu Zou、Chao Wang、Jen Smith、Dong Xue、Jianliang Xiao

  DOI：10.1002/chem.201501109

  日期：2015.6.26

  An efficient catalytic system for the alkylation of amines with either alcohols or amines under mild conditions has been developed, using cyclometallated iridium complexes as catalysts. The method has broad substrate scope, allowing for the synthesis of a diverse range of secondary and tertiary amines with good to excellent yields. By controlling the ratio of substrates, both mono‐ and bis‐alkylated

  使用环金属化铱配合物作为催化剂，已经开发出一种在温和条件下将胺与醇或胺烷基化的有效催化体系。该方法具有广泛的底物范围，允许以良好或优异的产率合成多种范围的仲胺和叔胺。通过控制底物的比例，可以高选择性获得单烷基化胺和双烷基化胺。特别是，甲醇可用作烷基化试剂，选择性地提供N-甲基化产物。对于该反应观察到强溶剂作用。
• Methods for treating cryptosporidiosis using triazolopyridazines
  申请人：University of Vermont and State Agricultural College

  公开号：US10363254B2

  公开（公告）日：2019-07-30

  Methods for treating or prophylaxis of a Cryptosporidium infection using compositions comprising a structure disclosed herein. Also provided are pharmaceutical compositions and kits for alleviating the symptoms of, for treating, or for preventing the occurrence of Cryptosporidium infection. The kits comprise one or more compounds having a structure disclosed herein, such as in an oral composition, and instructions for use, storage, and the like.

  使用包含本文公开的结构的组合物治疗或预防隐孢子虫感染的方法。还提供了用于缓解隐孢子虫感染症状、治疗或预防隐孢子虫感染发生的药物组合物和试剂盒。这些试剂盒包括一种或多种具有本文所公开结构的化合物，如口服组合物，以及使用、储存等说明。
• METHODS FOR TREATING CRYPTOSPORIDIOSIS USING TRIAZOLOPYRIDAZINES
  申请人：University of Vermont and State Agricultural College

  公开号：US20180064711A1

  公开（公告）日：2018-03-08

  Methods for treating or prophylaxis of a Cryptosporidium infection using compositions comprising a structure disclosed herein. Also provided are pharmaceutical compositions and kits for alleviating the symptoms of, for treating, or for preventing the occurrence of Cryptosporidium infection. The kits comprise one or more compounds having a structure disclosed herein, such as in an oral composition, and instructions for use, storage, and the like.
• ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
  申请人：Universal Display Corporation

  公开号：US20210253446A1

  公开（公告）日：2021-08-19

  Provided are organometallic compounds. Also provided are formulations comprising these organometallic compounds. Further provided are OLEDs and related consumer products that utilize these organometallic compounds.