4-Isopropylamino-2,6-dimethyl-pyrimidin | 2959-45-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Isopropylamino-2,6-dimethyl-pyrimidin
• 英文别名: (2,6-dimethyl-pyrimidin-4-yl)-isopropyl-amine；2,6-dimethyl-N-(propan-2-yl)pyrimidin-4-amine；2,6-dimethyl-N-propan-2-ylpyrimidin-4-amine
• CAS: 2959-45-7
• 化学式: C₉H₁₅N₃
• 分子量: 165.238
• InChiKey: HGRMARPJTMQCGH-UHFFFAOYSA-N

物化性质

• 沸点：
  137 °C(Press: 12 Torr)
• 密度：
  1.024±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Pyridopyrimidinone Inhibitors of PI3Kalpha
  申请人：Baik Tae-Gon

  公开号：US20110237608A1

  公开（公告）日：2011-09-29

  The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.

  本发明涉及式I的化合物及其药学上可接受的盐或溶剂，以及制备和使用这些化合物的方法。
• PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS
  申请人：Bebbington David

  公开号：US20100256170A1

  公开（公告）日：2010-10-07

  This invention describes novel pyrazole compounds of formula IV: wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R x and R y are independently selected from T-R 3 , or taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-8 membered ring having 1-3 ring heteroatoms selected from oxygen, sulfur, or nitrogen; and R 2 , R 2′ , T, and R 3 are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.

  本发明描述了式IV的新型吡唑化合物：其中环D为5-7成员单环或8-10成员双环，选自芳基，杂芳基，杂环基或碳环基；Rx和Ry分别选自T-R3，或与其之间的原子结合形成融合的、不饱和或部分不饱和的5-8成员环，其中有1-3个选自氧、硫或氮的环杂原子；R2、R2'、T和R3如说明书所述。这些化合物可用作蛋白激酶抑制剂，特别是aurora-2和GSK-3的抑制剂，用于治疗癌症、糖尿病和阿尔茨海默病等疾病。
• [EN] TYK2 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE TYK2 ET LEURS UTILISATIONS
  申请人：SUDO BIOSCIENCES LTD

  公开号：WO2022136914A1

  公开（公告）日：2022-06-30

  Described herein are compounds that are TYK2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of TYK2 activity.

  本文描述了TYK2抑制剂化合物，制备这些化合物的方法，包括这些化合物的药物组合物和药物，以及使用这些化合物治疗需要调节TYK2活性的疾病、病症或疾患的方法。
• US7473691B2
  申请人：——

  公开号：US7473691B2

  公开（公告）日：2009-01-06