(E)-2-hydroxy-N'-(1-(pyridin-2-yl)ethylidene)benzohydrazide | 109760-71-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-2-hydroxy-N'-(1-(pyridin-2-yl)ethylidene)benzohydrazide
• 英文别名: pyridine-2-acetaldehyde salicyloylhydrazone；2-hydroxy-N'-[1-(2-pyridinyl)ethylidene]benzohydrazide；2-hydroxy-N-[(E)-1-pyridin-2-ylethylideneamino]benzamide
• CAS: 109760-71-6
• 化学式: C₁₄H₁₃N₃O₂
• 分子量: 255.276
• InChiKey: CSTMGUNROPSAPK-MHWRWJLKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-乙酰基吡啶 、 水杨酰肼 反应 0.06h， 以95%的产率得到(E)-2-hydroxy-N'-(1-(pyridin-2-yl)ethylidene)benzohydrazide
  参考文献：
  名称：

  Fast Synthesis of N-Acylhydrazones Employing a Microwave Assisted Neat Protocol

  摘要：

  A variety of N-acylhydrazones were synthesized Under microwave irradiation within 2.5-10 min, starting from benzo, salicyloyl, and isonicotinic hydrazides. The protocol developed employs microwave irradiation in the absence of solvents and catalysts, leading to high yields. The results are reproducible in a 500 mg to 5 g scale.

  DOI：

  10.1021/cc9001444

文献信息

• Fast Synthesis of <i>N</i>-Acylhydrazones Employing a Microwave Assisted Neat Protocol
  作者：Marta M. Andrade、Maria Teresa Barros

  DOI：10.1021/cc9001444

  日期：2010.3.8

  A variety of N-acylhydrazones were synthesized Under microwave irradiation within 2.5-10 min, starting from benzo, salicyloyl, and isonicotinic hydrazides. The protocol developed employs microwave irradiation in the absence of solvents and catalysts, leading to high yields. The results are reproducible in a 500 mg to 5 g scale.