3-(acetoxymethyl)-7-<(5-nitrobenzimidazol-2-yl)amino>ceph-3-em-4-carboxylic acid | 79591-85-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 3-(acetoxymethyl)-7-<(5-nitrobenzimidazol-2-yl)amino>ceph-3-em-4-carboxylic acid
• CAS: 79591-85-8
• 化学式: C₁₇H₁₅N₅O₇S
• 分子量: 433.401
• InChiKey: LJHMTXGKBOZMDK-IUODEOHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.07
• 重原子数：
  30.0
• 可旋转键数：
  6.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  167.76
• 氢给体数：
  3.0
• 氢受体数：
  9.0

反应信息

• 作为产物：
  描述：

  tert-butyl (6R,7R)-3-(acetyloxymethyl)-7-[(6-nitro-1H-benzimidazol-2-yl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 在 三氟乙酸 作用下， 以 various solvent(s) 为溶剂， 反应 0.5h， 生成 3-(acetoxymethyl)-7-<(5-nitrobenzimidazol-2-yl)amino>ceph-3-em-4-carboxylic acid
  参考文献：
  名称：

  Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and .beta.-lactamase stability on the pKa of the C-7 heterocycle

  摘要：

  Cephalosporins with new aminobenzimidazole and aminoimidazoline heterocycles at C-7 have been synthesized starting with versatile C-7 isocyanide dihalide synthons. The aminobenzimidazoles have a broad spectrum of antibacterial activity, including Gram-positive and Gram-negative organisms, but possess limited beta-lactamase stability. In contrast, the aminoimidazolines have a narrow spectrum of antibacterial activity, limited to Gram-negative strains only, but possess outstanding beta-lactamase stability. Structure-activity relationships are discussed in terms of their dependence on the pK(a) of the C-7 amino heterocycle, basic C-7 residues giving cephalosporins with exceptional beta-lactamase stability.

  DOI：

  10.1021/jm00107a035