Catalytic Asymmetric Aldol-Type Reaction of Zinc Enolate Equivalent of Amides
作者:Ryosuke Haraguchi、Seijiro Matsubara
DOI:10.1021/ol401425s
日期:2013.7.5
Treatment of phenyl isocyanate with bis(iodozincio)methane gave a zinciomethylenated product, which acts as an amide-enoate equivalent. It did not react with an aldehyde efficiently, but gave the corresponding adduct in good yield in the presence of an aminoalcohol. Use of a catalytic amount of chiral aminoalcohol led the process to the catalytic asymmetric Aldol-type reaction.