1,4-bis(2-((S)-4-phenyl-4,5-dihydrooxazol-2-yl)propan-2-yl)phthalazine | 1301726-30-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1,4-bis(2-((S)-4-phenyl-4,5-dihydrooxazol-2-yl)propan-2-yl)phthalazine
• 英文别名: (4S)-4-phenyl-2-[2-[4-[2-[(4S)-4-phenyl-4,5-dihydro-1,3-oxazol-2-yl]propan-2-yl]phthalazin-1-yl]propan-2-yl]-4,5-dihydro-1,3-oxazole
• CAS: 1301726-30-6
• 化学式: C₃₂H₃₂N₄O₂
• 分子量: 504.632
• InChiKey: GCFVFKCXHDXUQI-CLJLJLNGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  69
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  L-苯甘氨醇 在 4-二甲氨基吡啶 、 甲基磺酰氯 、 三乙胺 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 1.0h， 生成 1,4-bis(2-((S)-4-phenyl-4,5-dihydrooxazol-2-yl)propan-2-yl)phthalazine
  参考文献：
  名称：

  Chiral dinuclear phthalazine bridged bisoxazoline ligands: synthesis and application in enantioselective Cu-catalyzed conjugate addition of ZnEt2 to enones

  摘要：

  A new class of chiral dinuclear ligands with phthalazine bridged bisoxazoline scaffold was designed and prepared in convenient synthetic routes. H-1 NMR analysis showed that this class of ligands could coordinate with two metal ions, either same or different. These ligands afforded good to excellent yields and enantioselectivities in Cu-catalyzed conjugate addition of ZnEt2 to enones. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.02.098
• 作为试剂：
  描述：

  4-(4-bromophenyl)but-3-en-2-one 、 diethylzinc 在 tetrakis(acetonitrile)copper(I)tetrafluoroborate 、 1,4-bis(2-((S)-4-phenyl-4,5-dihydrooxazol-2-yl)propan-2-yl)phthalazine 作用下， 以 乙醚 、 正己烷 、 二氯甲烷 为溶剂， 反应 18.0h， 生成 4-(p-bromo-phenyl)-hexan-2-one 、 4-(p-bromo-phenyl)-hexan-2-one
  参考文献：
  名称：

  Chiral dinuclear phthalazine bridged bisoxazoline ligands: synthesis and application in enantioselective Cu-catalyzed conjugate addition of ZnEt2 to enones

  摘要：

  A new class of chiral dinuclear ligands with phthalazine bridged bisoxazoline scaffold was designed and prepared in convenient synthetic routes. H-1 NMR analysis showed that this class of ligands could coordinate with two metal ions, either same or different. These ligands afforded good to excellent yields and enantioselectivities in Cu-catalyzed conjugate addition of ZnEt2 to enones. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.02.098

文献信息

• Chiral dinuclear phthalazine bridged bisoxazoline ligands: synthesis and application in enantioselective Cu-catalyzed conjugate addition of ZnEt2 to enones
  作者：Liang Zhang、Guoqiang Yang、Chaoren Shen、Sabah Arghib、Wanbin Zhang

  DOI：10.1016/j.tetlet.2011.02.098

  日期：2011.5

  A new class of chiral dinuclear ligands with phthalazine bridged bisoxazoline scaffold was designed and prepared in convenient synthetic routes. H-1 NMR analysis showed that this class of ligands could coordinate with two metal ions, either same or different. These ligands afforded good to excellent yields and enantioselectivities in Cu-catalyzed conjugate addition of ZnEt2 to enones. (C) 2011 Elsevier Ltd. All rights reserved.