(1,1-dioxidothiomorpholin-4-yl){4-[(2-fluoro-3-methylphenyl)amino]-5,6,7,8-tetrahydro-5,8-ethanoisoquinolin-1-yl}methanone | 1357190-23-8

• 分子结构分类: 有机化合物
• 英文名称: (1,1-dioxidothiomorpholin-4-yl){4-[(2-fluoro-3-methylphenyl)amino]-5,6,7,8-tetrahydro-5,8-ethanoisoquinolin-1-yl}methanone
• 英文别名: (1,1-Dioxo-1,4-thiazinan-4-yl)-[6-(2-fluoro-3-methylanilino)-4-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trien-3-yl]methanone
• CAS: 1357190-23-8
• 化学式: C₂₃H₂₆FN₃O₃S
• 分子量: 443.542
• InChiKey: HXIHQXLOCJVARS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  31
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  87.8
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• FUSED RING PYRIDINE COMPOUND
  申请人：Astellas Pharma Inc.

  公开号：US20130143874A1

  公开（公告）日：2013-06-06

  [Problem] To provide a compound useful as a novel agent which is excellent in preventing and/or treating cannabinoid receptor type 2-related diseases, based on agonist action on a cannabinoid receptor type 2 [Means for Solution] The present inventors conducted thorough investigation regarding compounds having agonist action on a cannabinoid receptor type 2. They confirmed that the fused ring pyridine compound of the present invention has excellent agonist action on the cannabinoid receptor type 2, thereby completing the present invention. The fused ring pyridine compound of the present invention has agonist action on the cannabinoid receptor type 2, and can be used as an agent for preventing and/or treating cannabinoid receptor type 2-related diseases, for example, inflammatory diseases and pain.

  [问题] 提供一种化合物，作为一种新型药剂，具有优异的防治大麻素受体类型2相关疾病的作用，基于对大麻素受体类型2的激动剂作用[解决方案] 本发明的发明人对具有大麻素受体类型2激动剂作用的化合物进行了彻底调查。他们确认本发明的融合环吡啶化合物在大麻素受体类型2上具有优异的激动剂作用，从而完成了本发明。本发明的融合环吡啶化合物在大麻素受体类型2上具有激动剂作用，可用作预防和/或治疗大麻素受体类型2相关疾病的药剂，例如炎症性疾病和疼痛。
• CONDENSED RING PYRIDINE COMPOUND
  申请人：Astellas Pharma Inc.

  公开号：EP2599774A1

  公开（公告）日：2013-06-05

  [Problem] To provide a compound useful as a novel agent which is excellent in preventing and/or treating cannabinoid receptor type 2-related diseases, based on agonist action on a cannabinoid receptor type 2 [Means for Solution] The present inventors conducted thorough investigation regarding compounds having agonist action on a cannabinoid receptor type 2. They confirmed that the fused ring pyridine compound of the present invention has excellent agonist action on the cannabinoid receptor type 2, thereby completing the present invention. The fused ring pyridine compound of the present invention has agonist action on the cannabinoid receptor type 2, and can be used as an agent for preventing and/or treating cannabinoid receptor type 2-related diseases, for example, inflammatory diseases and pain.

  [问题]基于对大麻素受体 2 型的激动剂作用，提供一种在预防和/或治疗与大麻素受体 2 型有关的疾病方面具有优异作用的新型制剂的化合物 [解决方法]本发明人对对大麻素受体 2 型具有激动作用的化合物进行了深入研究。他们证实本发明的融合环吡啶化合物对大麻素受体 2 型具有极好的激动作用，从而完成了本发明。本发明的融合环吡啶化合物对大麻素受体 2 型具有激动作用，可用作预防和/或治疗与大麻素受体 2 型有关的疾病（例如炎症性疾病和疼痛）的制剂。
• CONDENSED PYRIDINE COMPOUNDS AS CB2 CANNABINOID RECEPTOR LIGANDS
  申请人：Astellas Pharma Inc.

  公开号：EP2599774B1

  公开（公告）日：2016-07-06
• US8791106B2
  申请人：——

  公开号：US8791106B2

  公开（公告）日：2014-07-29