2-[3-(4-chloro-2-methylphenyl)-thioureido]-acetamide | 187866-84-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[3-(4-chloro-2-methylphenyl)-thioureido]-acetamide
• 英文别名: 2-[(4-chloro-2-methylphenyl)carbamothioylamino]acetamide
• CAS: 187866-84-8
• 化学式: C₁₀H₁₂ClN₃OS
• 分子量: 257.744
• InChiKey: APYZVDUJZGXGAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  99.2
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-[3-(4-chloro-2-methylphenyl)-thioureido]-acetamide 、 alkaline earth salt of/the/ methylsulfuric acid 以 乙醇 为溶剂， 生成 3-(4-Chloro-2-methylphenyl)-2-ethylsulfanyl-3,5-dihydroimidazol-4-one
  参考文献：
  名称：

  Effects of 2-(substituted-sulfanyl)-3,5-dihydro-imidazole-4-one and 2-(substituted-sulfanyl)-1H-imidazole-4,5-dione derivatives on serum HDL-cholesterol

  摘要：

  A series of 2-substituted sulfanyl-3,5-dihydro-imidazole-4-one and 2-substituted sulfanyl-1H-imidazole-4,5-diones was prepared and shown to increase high density lipoprotein cholesterol over other lipid fractions. Compound If showed efficacy in additional animal models. The major metabolite of If was isolated and its synthesis is reported. The effects of the metabolite on the lipid profile in rats were investigated. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00338-3
• 作为产物：
  描述：

  4-氯-2-甲基苯基异硫氰酸酯 、 甘氨酰胺 以 氯仿 为溶剂， 生成 2-[3-(4-chloro-2-methylphenyl)-thioureido]-acetamide
  参考文献：
  名称：

  Effects of 2-(substituted-sulfanyl)-3,5-dihydro-imidazole-4-one and 2-(substituted-sulfanyl)-1H-imidazole-4,5-dione derivatives on serum HDL-cholesterol

  摘要：

  A series of 2-substituted sulfanyl-3,5-dihydro-imidazole-4-one and 2-substituted sulfanyl-1H-imidazole-4,5-diones was prepared and shown to increase high density lipoprotein cholesterol over other lipid fractions. Compound If showed efficacy in additional animal models. The major metabolite of If was isolated and its synthesis is reported. The effects of the metabolite on the lipid profile in rats were investigated. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00338-3

文献信息

• 2-(substituted sulfanyl)-3,5-dihydro-imidazol-4-one derivatives for
  申请人：American Home Products Corporation

  公开号：US05599829A1

  公开（公告）日：1997-02-04

  A method for increasing blood serum HDL cholesterol levels in a mammal in need of increased HDL cholesterol blood serum levels, which comprises administering to said mammal, an effective amount of a compound of formula I: ##STR1## wherein R is phenyl or phenyl optionally substituted with one or more groups selected from halogen, alkyl, perfluoroalkyl, alkoxy, perfluoroalkoxy, hydroxy, alkanoyloxy, aroyloxy or arylalkanoyloxy; R.sup.3 is alkyl, aryl or arylalkyl; or a pharmaceutically acceptable salt thereof.

  一种用于增加需要增加高密度脂蛋白胆固醇血清水平的哺乳动物血清中高密度脂蛋白胆固醇水平的方法，包括向所述哺乳动物施用化合物I的有效量：##STR1##其中R是苯基或苯基，可选地取代为来自卤素、烷基、全氟烷基、烷氧基、全氟烷氧基、羟基、烷酰氧基、芳酰氧基或芳基烷酰氧基的一个或多个基团；R.sup.3是烷基、芳基或芳基烷基；或其药学上可接受的盐。
• 2-(substituted sulfanyl)-3,5-dihydro-imidazol-4-one derivatives
  申请人：American Home Products Corporation

  公开号：US05877324A1

  公开（公告）日：1999-03-02

  The compound of formula I: ##STR1## wherein R is phenyl or phenyl optionally substituted with one or more groups selected from halogen, alkyl, perfluoroalkyl, alkoxy, perfluoroalkoxy, hydroxy, alkanoyloxy, aroyloxy or arylalkanoyloxy; R.sup.3 is alkyl, aryl or arylalkyl; or a pharmaceutically acceptable salt thereof, are use for increasing HDL blood levels.

  式I的化合物：##STR1##其中R是苯基或苯基，可选地取代为卤素、烷基、全氟烷基、烷氧基、全氟烷氧基、羟基、烷酰氧基、芳酰氧基或芳基烷酰氧基中的一个或多个基团；R.sup.3是烷基、芳基或芳基烷基；或其药学上可接受的盐，用于增加HDL血液水平。
• 2-(SUBSTITUTED SULFANYL)-3,5-DIHYDRO-IMIDAZOL-4-ONE DERIVATIVES
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0876354A1

  公开（公告）日：1998-11-11
• US5599829A
  申请人：——

  公开号：US5599829A

  公开（公告）日：1997-02-04
• [EN] 2-(SUBSTITUTED SULFANYL)-3,5-DIHYDRO-IMIDAZOL-4-ONE DERIVATIVES<br/>[FR] DERIVES DE 2-(SUBSTITUTION SULFANYLE)-3,5-DIHYDROIMIDAZOL-4-ONE
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：WO1997019931A1

  公开（公告）日：1997-06-05

  (EN) The compounds of formula (I): wherein R is phenyl or phenyl optionally substituted with one or more groups selected from halogen, alkyl, perfluoroalkyl, alkoxy, perfluoroalkoxy, hydroxy, alkanoyloxy, aroyloxy or arylalkanoyloxy; R3 is alkyl, aryl or arylalkyl; or a pharmaceutically acceptable salt thereof, are use for increasing HDL blood levels.(FR) L'invention concerne un composé de la formule (I). Dans cette formule, R est un phényle éventuellement substitué avec un ou plusieurs groupes choisis parmi: halogène, alkyle, perfluoroalkyle, alcoxy, perfluoroalcoxy, hydroxy, alcanoyloxy, aroyloxy ou arylalcanoyloxy; R3 est un alkyle, aryle ou aralkyle. L'invention concerne également les sels de ces composés acceptables sur le plan pharmaceutique. Ces dérivés et leurs sels sont utiles pour augmenter les niveaux de HDL dans le sang.