(E)-1,1-diphenyl-N-((E)-3-phenylallylidene)methanamine | 169698-48-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-1,1-diphenyl-N-((E)-3-phenylallylidene)methanamine
• 英文别名: (E)-diphenyl-N-((E)-3-phenylallylidene)methanamine
• CAS: 169698-48-0
• 化学式: C₂₂H₁₉N
• 分子量: 297.4
• InChiKey: XZOOIBRWAUBGQE-QSUZBBGVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.56
• 重原子数：
  23.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  12.36
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (E)-1,1-diphenyl-N-((E)-3-phenylallylidene)methanamine 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 0.33h， 生成 (E)-N-benzhydryl-3-phenylprop-2-en-1-amine
  参考文献：
  名称：

  Synthesis and structure-activity relationships of naftifine-related allylamine antimycotics

  摘要：

  Naftifine (1) is the first representative of the new antifungal allylamine derivatives. Its biological activity is strictly bound to specific structural requirements that are unrelated to those of known antifungals. A tertiary allylamine function seems to be a prerequisite for activity against fungi. By systematic variation of the individual structural elements in 1, detailed structure-activity relationships are defined in which the phenyl ring is the structural feature permitting the widest variations. Versatile synthetic routes to allylamine derivatives and comparative biological data are presented.

  DOI：

  10.1021/jm00151a019
• 作为产物：
  描述：

  二苯甲胺 以51%的产率得到
  参考文献：
  名称：

  Bakibaew A. A., Akhmedzhanow R. R., Nowozheewa T. P., Tignibidina L. G., +, Khim.-farmach. zh., 27 (1993) N 4, S 39-41

  摘要：

  DOI：

文献信息

• Highly Enantioselective Titanium-Catalyzed Cyanation of Imines at Room Temperature
  作者：Abdul Majeed Seayad、Balamurugan Ramalingam、Kazuhiko Yoshinaga、Takushi Nagata、Christina L. L. Chai

  DOI：10.1021/ol902540h

  日期：2010.1.15

  A highly active and enantioselective titanium-catalyzed cyanation of imines at room temperature is described. The catalyst used is a partially hydrolyzed titanium alkoxide (PHTA) precatalyst together with a readily available N-salicyl-β-aminoalcohol ligand. Up to 98% ee was obtained with quantitative yields in 15 min of reaction time using 5 mol % of the catalyst. Various N-protecting groups such as

  描述了在室温下高活性和对映选择性的钛催化的亚胺氰化。所用的催化剂是部分水解的烷氧基钛（PHTA）预催化剂以及易于获得的N-水杨基-β-氨基醇配体。使用5 mol％的催化剂，在15分钟的反应时间内以定量收率获得了高达98％ee。可以耐受各种N保护基，例如苄基，苯甲基，Boc和PMP。
• TITANIUM COMPOUNDS AND PROCESS FOR CYANATION OF IMINES
  申请人：Seayad Abdul Majeed

  公开号：US20110319629A1

  公开（公告）日：2011-12-29

  The present invention relates to titanium catalysts for synthesis reactions produced by bringing a reaction mixture comprising a titanium alkoxide and a ligand in contact with water, wherein the ligand is represented by the general formula (e): wherein R 1 , R 2 , R 3 , and R 4 are independently a hydrogen atom, an alkyl group, or the like, and (A) represents a group with two or more carbon atoms. The titanium catalysts may be isolated in solid form and may be stored. The invention further relates to a process for cyanation of imines, wherein the process comprises reacting an imine with a cyanating agent in the presence of the titanium catalyst.

  本发明涉及一种通过使包含钛醇盐和配体的反应混合物与水接触而制得的用于合成反应的钛催化剂，其中配体由通式(e)表示：其中R1、R2、R3和R4各自独立地为氢原子、烷基组或其他类似物，且(A)表示具有两个或更多个碳原子的基团。所述钛催化剂可以以固体形式分离并储存。本发明还涉及一种亚胺的氰化方法，该方法包括在钛催化剂存在下使亚胺与氰化剂反应。
• COMPOUNDS AND RELATED METHODS OF USE
  申请人：Jacobsen Eric N.

  公开号：US20130066109A1

  公开（公告）日：2013-03-14

  Described herein are compounds of formula (I), related compositions, and their use, for example in the formation of α-amino acids or a precursor thereof such as an α-aminonitrile.

  本文描述了式（I）的化合物、相关组合物及其用途，例如在形成α-氨基酸或其前体（如α-氨基腈）中的应用。
• Double Nucleophilic Addition of Azide and Tetraallyltin to the Latent α,β-Unsaturated Aldehydes Using in situ Hydrolysis of the Imino Functionality Promoted by Tin(IV) Chloride Pentahydrate
  作者：Makoto Shimizu、Takafumi Nishi

  DOI：10.1055/s-2004-820023

  日期：——

  In the presence of SnCl4·5H2O and acetic acid, a mixture of trimethylsilyl azide and tetraallyltin underwent 1,4- and sub­sequently 1,2-addition, respectively, with the α,β-unsaturated ­aldimines to give 1,3-hydroxy azides in good yields, where the hydrolysis of the intermediary imino species was found to be crucial.

  在SnCl4·5H2O和醋酸的存在下，三甲基硅烷叠氮化物和四烯基锡的混合物与α,β-不饱和醛亚胺分别发生了1,4-和随后1,2-加成，生成了产率良好的1,3-羟基叠氮化物，其中中间亚胺物种的水解被发现是关键步骤。
• [EN] TITANIUM COMPOUNDS AND PROCESS FOR CYANATION OF IMINES<br/>[FR] COMPOSÉS DE TITANE ET PROCÉDÉ DE CYANATION DES IMINES
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2010093327A1

  公开（公告）日：2010-08-19

  The present invention relates to titanium catalysts for synthesis reactions produced by bringing a reaction mixture comprising a titanium alkoxide and a ligand in contact with water, wherein the ligand is represented by the general formula (e), wherein R1, R2, R3, and R4 are independently a hydrogen atom, an alkyl group, or the like, and (A) represents a group with two or more carbon atoms. The titanium catalysts may be isolated in solid form and may be stored. The invention further relates to a process for cyanation of imines, wherein the process comprises reacting an imine with a cyanating agent in the presence of the titanium catalyst.

  本发明涉及用于合成反应的钛催化剂，通过将包含钛烷氧化物和配体的反应混合物与水接触而产生，其中配体由通用公式（e）表示，其中R1、R2、R3和R4分别是氢原子、烷基或类似物，（A）代表具有两个或更多碳原子的基团。这些钛催化剂可以以固体形式分离并储存。该发明还涉及一种亚胺的氰化过程，其中该过程包括在钛催化剂存在下将亚胺与氰化剂反应。