1-LiO-2-[N(CH3)2CH2]C6H4 | 150544-42-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-LiO-2-[N(CH3)2CH2]C6H4
• 英文别名: lithium;2-[(dimethylamino)methyl]phenolate
• CAS: 150544-42-6
• 化学式: C₉H₁₂NO*Li
• 分子量: 157.141
• InChiKey: IEUBBXPFCOWJGO-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.17
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-LiO-2-[N(CH3)2CH2]C6H4 、 三氯化硼 以 甲苯 为溶剂， 以72%的产率得到
  参考文献：
  名称：

  Synthesis and spectroscopic studies on the base-stabilized aryloxyboron derivatives BX2{2-(NMe2CH2)OC6H4}, BX2{2-(NEt2CH2)OC6H4} and BX2{2,6-(NEt2CH2)2OC6H3}, (X=Cl, Et, H) and molecular structures of BCl2{2-(NEt2CH2)2OC6H4} and [BCl2{2-NHEt2CH2-6-(NEt2CH2)OC6H3}]Cl

  摘要：

  1-HO-2-(NMe2CH2)C6H4 (1a), 1-HO-2-(NEt2CH2)C6H4 (1b) and 1-HO-2,6-(NEt2CH2)(2)C6H3 (1c) reacted with BuLi to give the lithium salts 1-LiO-2-(NMe2CH2)C6H4 (2a) and 1-LiO-2,6-(NEt2CH2)(2)C6H3 (2c) or the phenol adducts [{1-LiO-2- (NR2CH2)C6H4}(2){1-HO-2-(NR2CH2)C6H4}] (R = Me (3a), Et (3b)). The phenol derivatives 1a-c reacted with BEt3 or BH3. thf with elimination of EtH or H-2 to give BX2 {2-(NMe2CH2)OC6H4} (X = Et (4a). H (5a)), BX2 {2-(NEt2CH2)OC6H4} (X = Et (4b), H (5b)) and BX2(2,6-(NEt2CH2)(2)OC6H3} (X=Et (4c), H (5c)). The reaction of 2a and 3b with BCl3 in toluene yielded BCl2 {2-(NMe2CH2)OC6H4} (6a) and BCl2{2-(NEt2CH2)OC6H4) (6b), while 2c afforded a mixture of BCl2{2,6-(NEt2CH2)(2)OC6H3} (6c) and BCl2{2-N(BCl3)Et2CH2-6-(NEt2CH2)OC6H3} (6c . BCl3). Treatment of this mixture with [PPh4]Cl gave [BCl2{2-NHEt2CH2-6-(NEt2CH2)OC6H3}]Cl (6c . HCl). The HCl-free product 6c was obtained from 6c . HCl and NaH. Compounds 2-6 and 6c . HCl were characterized spectroscopically (NMRI, IR), 5a and 6a-c also by MS, and crystal structures were determined for 6b and 6c . HCl. The borane derivatives 4-6 exhibit dynamic behavior in solution (ring opening and ring inversion), which was studied by VT H-1 NMR spectroscopy. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0277-5387(01)00746-x

文献信息

• Tungsten(VI) phenylimido alkylidene complexes containing a monoanionic O,N-chelating ligand and their isolated precursor complexes: x-ray structures of W(CH2SiMe3)3(:NPh)[OCPh2(2-py)] and W(:CHSiMe3)(CH2SiMe3)(:NPh)[OCPh2(2-py)]
  作者：Paul A. van der Schaaf、Robertus A. T. M. Abbenhuis、Walter P. A. van der Noort、Robin de Graaf、David M. Grove、Wilberth J. J. Smeets、Anthony L. Spek、Gerard van Koten

  DOI：10.1021/om00016a051

  日期：1994.4

  The lithium salts of selected phenoxides, with one or two potentially chelating o-CH2NMe2 substituents, 8-quinolinolate (8-quin), ortho-chelating arenethiolate ligands, and a-substituted 2-pyridylmethoxides, were reacted with W(CH2SiMe3)3Cl(=NPh) (1) and W(CH2SiMe3)2Cl-(=NPh)(OCMe3) (2), respectively. It appears that steric properties of the monoanionic O,N- and S,N-chelating ligands are very important for inducing an intramolecular H(alpha)-abstraction reaction; i.e., the phenoxide OC6H4CH2NMe2-2 (a) gave rise to the formation of alkylidene precursor W(CH2SiMe3)3(=NPh)(OC6H4CH2NMe2-2) (3), in which the alkyl groups are still intact, whereas the ''pincer phenolate'' OC6H2(CH2NMe2)2-2,6-Me-4 (b), with two o-CH2NMe2 substituents, directly led to the formation of alkylidene complex W(=CHSiMe3)(CH2SiMe3)(=NPh)(OC6H2(CH2NMe2)2-2,6-Me-4) (4'). The reaction of 1 with Na-8-quin instantaneously gave W(=CHSiMe3)(CH2SiMe3)(=NPh)(8-quin) (5'). Also, electronic properties play an important role in the formation of alkylidene complexes; i.e., the complexes derived from 2, containing a pi-electron-donating tert-butoxide group, are thermally more stable toward intramolecular H(alpha) abstraction than those derived from 1. With the alpha-substituted 2-pyridylmethoxide ligands OR1R2(2-py), in which the R substituents can be varied easily, we were able to prepare both the alkylidene precursor and the subsequent product of an intramolecular H(alpha)-abstraction reaction, the tungsten(VI) alkylidene complex. The solid-state structure (X-ray) of the trialkyltungsten(VI) precursor W(CH2SiMe3)3(=NPh)[OCPh2(2-py)] (9) as well as the resulting alkylidene complex W(=CHSiMe3)(CH2SiMe3)(=NPh)[OCPh2(2-py)] (9') have been determined. Crystals of 9 are monoclinic, space group P2(1)/c, with unit-cell dimensions a = 10.974(1) angstrom, b = 18.531(3) angstrom, and c = 20.307(2) angstrom, beta = 106.47(1)degrees, Z = 4, final R = 0.063, and R(w) = 0.053 for 2644 reflections with I > 2.5sigma(I) and 415 parameters. Crystals of 9' are triclinic, space group P1BAR, with unit-cell dimensions a = 9.4359(5) angstrom, b = 10-8887(7) angstrom, and c 16.611(1) alpha = 81.60(1)degrees, beta = 88.37(1)degrees, gamma = 79.19(1)degrees, Z=2, final R=0.042, and R(w) = 0.026 for 5879 reflections with I > 2.5sigma(I) and 348 parameters. The two molecular structures clearly show the advantage of a d0 metal center in forming an alkylidene unit out of two alkyl groups. The chemical shift of H-6, the hydrogen atom bonded at the ortho position with respect to the pyridyl nitrogen, as a probe shows that the pyridyl group in alkylidene complexes 9' and W(=CHSiMe3)(CH2SiMe3)(=NPh)[OCH(CMe3)(2-py)] (10') can coordinate intramolecularly in the syn rotamer, whereas in the anti rotamer this will lead to considerable steric hindrance of the SiMe3 group of the alkylidene function with the vicinal substituents in the chelating ring. The reactivity of the present tungsten(VI) alkylidene complexes 5', 9.', and 10' toward linear olefins is very low. However, aldehydes react with these complexes in Wittig-type reactions to yield predominantly the corresponding trans-olefin. Norbornene can be polymerized using these alkylidene complexes as a catalyst in a ring-opening metathesis reaction at 70-degrees-C to give polymeric cyclopentenes with greater-than-or-equal-to 90% cis vinylene bonds.
• Van Der Schaaf, Paul A.; Boersma, Jaap; Smeets, Wilbert J. J., Inorganic Chemistry, 1993, vol. 32, # 23, p. 5108 - 5113
  作者：Van Der Schaaf, Paul A.、Boersma, Jaap、Smeets, Wilbert J. J.、Spek, Anthony L.、Van Koten, Gerard

  DOI：——

  日期：——