Methanesulfonic acid (1S,2S,3S,4S)-2,3-bis-benzyloxy-4-methanesulfonyloxy-1-methyl-pentyl ester | 762300-72-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methanesulfonic acid (1S,2S,3S,4S)-2,3-bis-benzyloxy-4-methanesulfonyloxy-1-methyl-pentyl ester
• 英文别名: [(2S,3S,4S,5S)-5-methylsulfonyloxy-3,4-bis(phenylmethoxy)hexan-2-yl] methanesulfonate
• CAS: 762300-72-1
• 化学式: C₂₂H₃₀O₈S₂
• 分子量: 486.607
• InChiKey: JDWSIIFVQHAQQJ-MOXQZVSFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  32
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  122
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  二苯基膦酸锂 、 Methanesulfonic acid (1S,2S,3S,4S)-2,3-bis-benzyloxy-4-methanesulfonyloxy-1-methyl-pentyl ester 以 四氢呋喃 为溶剂， 以30%的产率得到[(2R,3S,4S,5R)-5-diphenylphosphanyl-3,4-bis(phenylmethoxy)hexan-2-yl]-diphenylphosphane
  参考文献：
  名称：

  Development of DIOP derivatives as efficient ligands for asymmetric hydrogenation: factors controlling the reactivities and enantioselectivities

  摘要：

  Several DIOP derivatives have been developed as efficient ligands for Rh and Ir-catalyzed asymmetric hydrogenations. The conformational mobility of the backbone in this type of ligand plays an important role in governing both the reactivity and enantioselectivity. Isolation of pure pre-catalyst is another key factor to obtain high catalytic activity. (C) 2004 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetasy.2004.05.042
• 作为产物：
  描述：

  1,2:5,6-dianhydro-3,4-di-O-benzyl-L-iditol 在 三乙基硼氢化锂 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 Methanesulfonic acid (1S,2S,3S,4S)-2,3-bis-benzyloxy-4-methanesulfonyloxy-1-methyl-pentyl ester
  参考文献：
  名称：

  Development of DIOP derivatives as efficient ligands for asymmetric hydrogenation: factors controlling the reactivities and enantioselectivities

  摘要：

  Several DIOP derivatives have been developed as efficient ligands for Rh and Ir-catalyzed asymmetric hydrogenations. The conformational mobility of the backbone in this type of ligand plays an important role in governing both the reactivity and enantioselectivity. Isolation of pure pre-catalyst is another key factor to obtain high catalytic activity. (C) 2004 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetasy.2004.05.042