3-bromo-2-methyl-heptane | 855895-05-5

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机溴化物
• 英文名称: 3-bromo-2-methyl-heptane
• 英文别名: 3-Brom-2-methyl-heptan；3-Bromo-2-methylheptane
• CAS: 855895-05-5
• 化学式: C₈H₁₇Br
• 分子量: 193.127
• InChiKey: YAOAFMWCTJRSFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  3-bromo-2-methyl-heptane 在 乙醇 、 sodium disulfide 作用下， 生成 bis-(1-isopropyl-pentyl)-disulfide
  参考文献：
  名称：

  Mel'nikow; Wol'fson, Zhurnal Obshchei Khimii, 1950, vol. 20, p. 2085;engl.Ausg.S.2159

  摘要：

  DOI：
• 作为产物：
  描述：

  2-甲基-3-庚醇 在 氢溴酸 作用下， 生成 3-bromo-2-methyl-heptane
  参考文献：
  名称：

  Tuot, Bulletin de la Societe Chimique de France, 1946, p. 366

  摘要：

  DOI：

文献信息

• Phthalocyanine compounds and optical recording media comprising them
  申请人：MITSUI CHEMICALS, INC.

  公开号：EP0719839B1

  公开（公告）日：2001-07-25
• NOVEL BIS-AMIDE DERIVATIVE AND USE THEREOF
  申请人：UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY

  公开号：US20160297751A1

  公开（公告）日：2016-10-13

  The present invention relates to a novel bis-amide derivative compound or a pharmaceutically acceptable salt thereof; a method of preparation thereof; and a pharmaceutical composition for preventing or treating diseases caused by hepatitis C virus infection and health functional food for preventing or ameliorating diseases caused by hepatitis C virus infection, containing the bis-amide derivative compound or a pharmaceutically acceptable salt thereof as an active ingredient. The novel bis-amide derivative compound of the present invention, particularly WJCPA-126, specifically binds to the catalytic site of CypA to effectively inhibit the activity of an isomerase, and the duration of the inhibitory effect can be increased because WJCPA-126 binds to CypA with high binding affinity exhibiting a low dissociation rate (K off ). Accordingly, WJCPA-126 has nontoxic and non-immunosuppressive characteristics and can effectively inhibit HCV replication in vitro and in vivo model systems. Additionally, WJCPA-126 reactivates the host interferon response through an increase in the expression of IFN-stimulated genes (ISGs) and the inhibition of interleukin-8 (IL-8) secretion. Therefore, a series of the bis-amide derivatives including WJCPA-126 can be useful as a novel type CypA inhibitor exhibiting antiviral effect.
• US5693396A
  申请人：——

  公开号：US5693396A

  公开（公告）日：1997-12-02