3,4,5,7-tetra-O-benzyl-2,6-dideoxy-2,6-imino-D-glycero-D-galacto-heptitol O(7),N-cyclic carbamate | 1227700-64-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4,5,7-tetra-O-benzyl-2,6-dideoxy-2,6-imino-D-glycero-D-galacto-heptitol O(7),N-cyclic carbamate
• CAS: 1227700-64-2
• 化学式: C₃₅H₃₉NO₅
• 分子量: 553.698
• InChiKey: VRPQFSTYPAXDTD-HPRFQDQJSA-N

反应信息

• 作为反应物：
  描述：

  草酸醛 、 3,4,5,7-tetra-O-benzyl-2,6-dideoxy-2,6-imino-D-glycero-D-galacto-heptitol O(7),N-cyclic carbamate 在 水 、 溶剂黄146 、 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Synthesis of N-substituted iminosugar derivatives and their immunosuppressive activities

  摘要：

  Several N-alkyl and hydroxyethyl-substituted iminosugar derivatives, including L-altro and D-galacto epimers, were synthesized and the effects of these synthetic iminosugars on proliferation of mouse splenocytes were evaluated in the MTT assay. The experimental data demonstrated that the N-alkylated D-galacto iminosugars showed better inhibitory activities than L-altro analogues, which might hold potential as immunosuppressive agents. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2010.01.021
• 作为产物：
  描述：

  1,3,4,5-tetra-O-benzyl-2,6-dideoxy-2,6-imino-D-glycero-L-galacto-heptitol O(7),N-cyclic carbamate 在 水 、 potassium hydroxide 作用下， 以 甲醇 为溶剂， 反应 20.0h， 以85%的产率得到3,4,5,7-tetra-O-benzyl-2,6-dideoxy-2,6-imino-D-glycero-D-galacto-heptitol O(7),N-cyclic carbamate
  参考文献：
  名称：

  Synthesis of N-substituted iminosugar derivatives and their immunosuppressive activities

  摘要：

  Several N-alkyl and hydroxyethyl-substituted iminosugar derivatives, including L-altro and D-galacto epimers, were synthesized and the effects of these synthetic iminosugars on proliferation of mouse splenocytes were evaluated in the MTT assay. The experimental data demonstrated that the N-alkylated D-galacto iminosugars showed better inhibitory activities than L-altro analogues, which might hold potential as immunosuppressive agents. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2010.01.021