3,5-二氨基-N-(氨基硫代甲酰基)-6-氯-2-吡嗪甲酰胺 | 30478-39-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 3,5-二氨基-N-(氨基硫代甲酰基)-6-氯-2-吡嗪甲酰胺
• 英文名称: (3,5-Diamino-6-chlorpyrazinoyl)thioharnstoff
• 英文别名: 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid thiocarbamoylamide；3,5-Diamino-N-carbamothioyl-6-chloropyrazine-2-carboxamide
• CAS: 30478-39-8
• 化学式: C₆H₇ClN₆OS
• 分子量: 246.68
• InChiKey: ULENEAJYRCAGBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  165
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Novel heterocyclic substituted pyrazinoylguanidines, processes for preparing and a pharmaceutical composition containing the same
  申请人：Merck & Co., Inc.

  公开号：EP0017152A1

  公开（公告）日：1980-10-15

  The case involves novel heterocyclic substituted pyrazinoylguanidines, their pharmaceutically acceptable non-toxic addition salts and a process for preparing same. The novel pyrazinoylguanidines have the general formula wherein R2 is hydrogen, lower alkyl having from 1 to 5 carbon atoms; R2 is hydrogen, lower alkyl having 1 to 5 carbon atoms; R3 is a 5 or 6 membered heterocyclic ring containing from 1 to 3 heterocyclic atoms selected from the elements N. α or S, said ring containing from 0 to 2 substituents selected from lower alkyl having 1 to 5 carbon atoms, halo, oxy or hydroxy; X is halo. They are eukalemic agents possessing diuretic and natriuretic properties.

  本案涉及新型杂环取代的吡嗪酰胍类化合物、其药学上可接受的无毒加成盐及其制备方法。新型吡嗪酰胍的通式为 其中 R2 是氢、具有 1 至 5 个碳原子的低级烷基； R2 是氢、具有 1 至 5 个碳原子的低级烷基 R3 是 5 或 6 个成员的杂环，含有 1 至 3 个选自 N、α 或 S 元素的杂环原子，所述环含有 0 至 2 个选自具有 1 至 5 个碳原子的低级烷基、卤代、氧基或羟基的取代基； X 为卤代。 它们是具有利尿和利钠特性的真核生物制剂。
• US4246406A
  申请人：——

  公开号：US4246406A

  公开（公告）日：1981-01-20
• US7399766B2
  申请人：——

  公开号：US7399766B2

  公开（公告）日：2008-07-15
• [EN] POLY AROMATIC SODIUM CHANNEL BLOCKERS<br/>[FR] BLOQUEURS POLY-AROMATIQUES DE CANAUX SODIQUES
  申请人：JOHNSON MICHAEL R

  公开号：WO2009139948A1

  公开（公告）日：2009-11-19

  Polyaromatic sodium channel blockers represented by the formula: ( I ) are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.
• [EN] PRODUCTION METHOD OF PHENYL GUANIDINE SALTS AND THEIR INTERMEDIATES<br/>[FR] PROCÉDÉ DE PRODUCTION DE SELS DE PHÉNYLGUANIDINE ET DE LEURS INTERMÉDIAIRES
  申请人：KAINOS MEDICINE INC

  公开号：WO2011156355A1

  公开（公告）日：2011-12-15

  This invention relates to methods for producing phenyl guanidine salts having pharmacological activity, as well as to the identification and synthesis of compounds useful as intermediates for producing phenyl guanidine salts having pharmacological activity.