磷酸二氟菊酯 | 84958-45-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 磷酸二氟菊酯
• 中文别名: 二氟尼柳磷酸酯
• 英文名称: Diflunisal Phosphate
• 英文别名: 5-(2,4-difluorophenyl)-2-phosphonooxybenzoic acid
• CAS: 84958-45-2
• 化学式: C₁₃H₉F₂O₆P
• 分子量: 330.18
• InChiKey: PBINCWMWAIMYCR-UHFFFAOYSA-N

物化性质

• 熔点：
  161-163°C
• 沸点：
  546.4±60.0 °C(Predicted)
• 密度：
  1.631±0.06 g/cm3(Predicted)
• 溶解度：
  DMSO（微溶）、甲醇（微溶）、水（微溶、加热）

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  二氟尼柳 生成 磷酸二氟菊酯
  参考文献：
  名称：

  BRUGIONI, M.;FEDI, M.

  摘要：

  DOI：

文献信息

• MARKERS ASSOCIATED WITH ENDOMETRIAL DISEASE
  申请人：Mount Sinai Hospital Corporation

  公开号：EP2251695A2

  公开（公告）日：2010-11-17

  Methods for detecting endometrial diseases or an endometrium phase in a subject are described comprising measuring endometrial markers or polynucleotides encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for endometrial diseases, and kits for carrying out the methods of the invention. The invention also contemplates therapeutic applications for endometrial diseases employing endometrial markers, polynucleotides encoding the markers, and/or binding agents for the markers.

  本发明描述了检测受试者子宫内膜疾病或子宫内膜阶段的方法，包括测量受试者样本中的子宫内膜标记物或编码标记物的多核苷酸。本发明还提供了子宫内膜疾病的定位或成像方法，以及实施本发明方法的试剂盒。本发明还考虑利用子宫内膜标记物、编码标记物的多核苷酸和/或标记物的结合剂来治疗子宫内膜疾病。
• Markers of the male urogenital tract
  申请人：Sinai Health System

  公开号：US10006921B2

  公开（公告）日：2018-06-26

  Methods for detecting urogenital conditions or urogenital status in a subject are described comprising measuring urogenital markers or polynucleotides, encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for urogenital conditions, and kits for carrying out the methods of the invention. The invention also contemplates therapeutic applications for urogenital conditions employing urogenital markers, polynucleotides encoding the markers, and/or binding agents for the markers.

  本发明描述了检测受试者泌尿生殖系统状况或泌尿生殖系统状态的方法，包括测量受试者样本中的泌尿生殖系统标记物或编码标记物的多核苷酸。本发明还提供了泌尿生殖系统疾病的定位或成像方法，以及用于实施本发明方法的试剂盒。本发明还考虑利用泌尿生殖系统标记物、编码标记物的多核苷酸和/或标记物的结合剂对泌尿生殖系统疾病进行治疗。
• Methods for detecting Alzheimers disease
  申请人：Mount Sinai Hospital

  公开号：US20020182644A1

  公开（公告）日：2002-12-05

  Methods for diagnosing and monitoring Alzheimer's Disease in a subject comprising measuring hK6 in a sample from the subject. hK6 may be measured using a reagent that detects or binds to hK6, preferably antibodies reactive with hK6.

  用于诊断和监测受试者阿尔茨海默病的方法包括测量受试者样本中的 hK6。
• Methods for detecting ovarian cancer
  申请人：——

  公开号：US20040096915A1

  公开（公告）日：2004-05-20

  A method for the diagnosis, prognosis, and monitoring of ovarian cancer in a subject by detecting hK6 in a sample from the subject, preferably a serum sample or tumor tissue extract. hK6 may be measured using a reagent that detects or binds to hK6 preferably antibodies specifically reactive with hK6 or a part thereof. Imaging methods for tumors associated with hK6 are also described using an agent that binds to hK6 which has a label for imaging the tumor.

  一种通过检测受试者样本（最好是血清样本或肿瘤组织提取物）中的 hK6 来诊断、预后和监测受试者卵巢癌的方法。hK6 可使用检测或结合 hK6 的试剂（最好是与 hK6 或其部分特异性反应的抗体）来测量。还描述了与 hK6 相关的肿瘤成像方法，使用与 hK6 结合的试剂，该试剂具有肿瘤成像标签。
• Method of detecting and monitoring prostate and ovarian cancers
  申请人：——

  公开号：US20040203012A1

  公开（公告）日：2004-10-14

  A method for the diagnosis, prognosis, and monitoring of ovarian or prostate cancer in a subject by detecting hK11 in a sample from the subject, preferably a serum sample. hK11 may be measured using a reagent that detects or binds to hK11 preferably antibodies specifically reactive with hK11 or a part thereof. Imaging methods for tumors associated with hK11 are also described using an agent that binds to hK11 which has a label for imaging the tumor.

  一种通过检测受试者样本（最好是血清样本）中的 hK11 来诊断、预后和监测受试者卵巢癌或前列腺癌的方法。还描述了与 hK11 相关的肿瘤成像方法，使用与 hK11 结合的试剂，该试剂具有肿瘤成像标签。