5-(2,6-Dichlorobenzoyl)-2',3',5'-tri-O-benzoyluridine oxime | 135073-77-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 5-(2,6-Dichlorobenzoyl)-2',3',5'-tri-O-benzoyluridine oxime
• CAS: 135073-77-7
• 化学式: C₃₇H₂₇Cl₂N₃O₁₀
• 分子量: 744.541
• InChiKey: NNPJACDTLXGHFX-UGUWQOMFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.28
• 重原子数：
  52.0
• 可旋转键数：
  10.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  175.58
• 氢给体数：
  2.0
• 氢受体数：
  12.0

反应信息

• 作为产物：
  描述：

  2,6-dichlorobenzohydroximoyl chloride 、 2,3,5-三苯甲酰尿苷 在 三乙胺 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 72.0h， 以83%的产率得到5-(2,6-Dichlorobenzoyl)-2',3',5'-tri-O-benzoyluridine oxime
  参考文献：
  名称：

  Reactivity of nitrile oxides toward the 5,6-double bond of uracil derivatives: synthesis of some 5-aroylpyrimidine nucleoside oximes

  摘要：

  The 5-aroylpyrimidine nucleoside oximes 3-10 were prepared in moderate to good yield by the reaction of the corresponding pyrimidine nucleosides 2a-d with stable nitrile oxides. The nitrile oxides were generated in situ from the corresponding hydroximoyl chlorides 1a-e. From these reactions, only the 1,3-addition products 3-10 were obtained. No products of cycloaddition could be isolated. The 1,3-addition products 3-10 could be formed from the ring-opening reaction of the initially formed 1,3-cycloaddition products. Evidence that supports the proposed mechanism came from experiments that used 1,3-dimethyluracil (13) as the substrate.

  DOI：

  10.1021/jo00030a011

文献信息

• A Study on the Ring Transformation of Dihydroisoxazolopyrimidine
  作者：Jae Nyoung Kim、Hong Jung Lee、Hyoung Rae Kim、Eung K. Ryu

  DOI：10.1080/00397919708005650

  日期：1997.10

  Dihydroisoxazolopyrimidine derivatives could be cleaved to form either pyrimidine ring or isoxazole ring derivatives depending upon the reaction conditions employed.