4-Methyl-cyclohexanesulfonyl chloride | 1249267-54-6

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 磺酰卤
• 英文名称: 4-Methyl-cyclohexanesulfonyl chloride
• 英文别名: 4-Methylcyclohexane-1-sulfonyl chloride
• CAS: 1249267-54-6
• 化学式: C₇H₁₃ClO₂S
• 分子量: 196.698
• InChiKey: BJYALKVVPOIVFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Methyl-cyclohexanesulfonyl chloride 在 potassium fluoride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 4-Methylcyclohexylsulfofluorid
  参考文献：
  名称：

  Matyschok,H. et al., Journal fur praktische Chemie (Leipzig 1954), 1977, vol. 319, p. 46 - 52

  摘要：

  DOI：

文献信息

• Substituted 5-cyanoindole compounds and uses thereof
  申请人：Novartis AG

  公开号：US10604502B2

  公开（公告）日：2020-03-31

  A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for the treatment of lysine (K)-specific demethylase 1A (LSD1)-mediated diseases or disorders: wherein R1, R2, R3, R4, and R5 are as defined herein.

  本研究提供了一种式（I）化合物或其药学上可接受的盐，该化合物已被证明可用于治疗赖氨酸（K）特异性去甲基化酶 1A (LSD1)介导的疾病或失调： 其中 R1、R2、R3、R4 和 R5 如本文所定义。
• Scavenger supports and the use thereof in a process for the extraction of metals
  申请人：Pears David Alan

  公开号：US20090023604A1

  公开（公告）日：2009-01-22

  There is provided a process for removing metal from solution wherein a solution comprising a metal is contacted with a scavenger support, whereby the scavenger support binds to at least some of the metal in solution thereby decreasing the amount of metal in solution, characterised in that the scavenger support comprises a functionalised support comprising pendant groups selected from 1,3-ketoesters or 1,3-ketoamides or mixtures thereof attached to a support wherein a number of the pendant groups are reacted with an amine. Scavenger supports comprising a functionalised support comprising pendant 1,3-ketoester or 1,3-ketoamide groups of formula 1: wherein R 1 is an optionally substituted hydrocarbyl, perhalogenated hydrocarbyl or heterocyclyl group; X is O or NR 2 , wherein the free valence of O or NR 2 is bonded to a support optionally via a linker; and R 2 is hydrogen, an optionally substituted hydrocarbyl, or heterocyclyl group, wherein a number of the pendant groups are reacted with an amine are also provided. Preferred scavenger supports include scavenger supports comprising pendant 3-iminoesters, 3-iminoamides, 2,3-enaminoesters or 2,3-enaminoamides pendant groups of Formula (3) or (4): wherein R 1 is an optionally substituted hydrocarbyl, perhalogenated hydrocarbyl or heterocyclyl group; X is O or NR 2 , wherein the free valence of O or NR 2 is bonded to a support optionally via a linker; R 2 is hydrogen, an optionally substituted hydrocarbyl, or heterocyclyl group; R 4 is a substituent group; and R 5 is hydrogen or a substituent group, or R 4 and R 5 may optionally be linked in such a way so as to form an optionally substituted heterocyclic ring, or tautomers or salts thereof.
• IMMUNOASSAY OF S-ADENOSYLMETHIONINE IN PERSONALIZED MEDICINE AND HEALTH OR CANCER EVALUATION
  申请人：Hao Xiujuan

  公开号：US20150268231A1

  公开（公告）日：2015-09-24

  The invention provides a method of detecting the presence or absence of a disease in a patient wherein said disease is accompanied by deficient levels of S-adenosylmethionine comprising: identifying a patient that is suspected of having said disease or is at risk of having said disease; obtaining a biological sample from said patient; determining the level of S-adenosylmethionine in said biological sample using an antibody derived from a hapten analog of S-adenosylmethionine; and correlating the level of S-adenosylmethionine in said biological sample with the presence, absence, or severity of said disease. The invention also provides methods for measuring SAH which is used to determine the methylation index (ratio of SAM/SAH) in biological fluids which is indicative of the health status of an individual. Additionally, the invention includes test strips which are useful for determining S-adenosylmethionine and S-adenosylhomocysteine.
• SUBSTITUTED 5-CYANOINDOLE COMPOUNDS AND USES THEREOF
  申请人：Novartis AG

  公开号：US20190023684A1

  公开（公告）日：2019-01-24

  A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for the treatment of lysine (K)-specific demethylase 1A (LSD1)-mediated diseases or disorders: wherein R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein.
• US7264792B2
  申请人：——

  公开号：US7264792B2

  公开（公告）日：2007-09-04